作用:(1)特异性结合抗原:Anti-CCP本身不能直接溶解或杀伤带有特异抗原的靶细胞,通常需要补体或吞噬细胞等共同发挥效应以清除病原微生物或导致病理损伤。然而,抗体可通过与病毒或毒素的特异性结合,直接发挥中和病毒的作用。 (2)激活补体:IgM、IgG1、IgG2和IgG3可通过经典途径激活补体,凝聚的IgA、IgG4和IgE可通过替...
关于抗环瓜氨酸肽抗体(anti-CCP antibody ),以下描述错误的是 A. 以IgG型为主的抗体 B. 可鉴别侵蚀性,非侵蚀性类风湿性关节炎 C. 特异性不如R
Martinsson, K.Johansson, A.Kastbom, A.Skogh, T.Clinical & Experimental ImmunologyMartinsson K, Johansson A, Kastbom A, et al. Immunoglobulin (Ig)G1 and IgG4 anti-cyclic citrullinated peptide (CCP) associate with shared epitope, whereas IgG2 anti-CCP associates with smoking in patients with ...
英文名称:anti-cyclicpeptidecontainingcitrulline3antibody/anti-CCP3-abkit 货号:BYP37767R 检测范围:0.3125-10ng/ml 规格:96T/48T 人抗环瓜氨酸多肽3抗体(anti-CCP3-ab)elisa试剂盒实验原理: 本试剂盒应用双抗体夹心法测定标本。用纯化的试剂抗体包被微孔板,制成固相抗体,往包被单抗的微孔中依次加入它,再与HRP...
To determine the accuracy of newer biomarkers for RA testing for antibody against cyclic citrullinated peptides (anti‐CCP Ab), IgA‐ and IgG‐RF and ... C Nikolaisen,OP Rekvig,HC Nossent - 《Scandinavian Journal of Rheumatology》 被引量: 44发表: 2009年 ...
进一步分析了anti-CSP与anti-CCP联合用于RA诊断的灵敏度和特异性。anti-CSP和anti-CCP的组合显示敏感性提高,同时保持了高特异性。与其他新兴生物标志物相比,anti-CSP显示出相当或更好的诊断价值。它与anti-CCP联合使用对RA具有卓越的诊断效率。 图3 anti-CSP、anti-CCP及其联合用于RA诊断的ROC曲线 ...
探讨抗Sa抗体、抗环瓜氨酸肽(CCP)抗体、GPI抗原及类风湿因子联合检测对类风湿关节炎诊断的意义。 方法:(1)采用ELISA法对确诊为RA的患者97例、其他自身免疫疾病组67例及健康对照组49例人群的抗Sa抗体、抗CCP抗体、GPI抗原及RF亚型RF-IgA、RF-IgG、RF-IgM进行检测,免疫比浊法检测RF。
Serum samples were analyzed for the presence of anti-CCP (IgG, IgA), RF (IgM, IgA) and anti-RA33 (IgM, IgA, IgG) using the EliA TM instrument platform (Phadia AB, Uppsala, Sweden). Genetic measurements were performed using ... M Grundhuber,I Gehring,C Lamacchia,... - 《Annals of...
The ELISA kits under study were IMMUNOSCAN RA (Euro-Diagnostica AB), QUANTA Lite™ CCP IgG ELISA (INOVA Diagnostic) and DIA-STAT™ Anti-CCP (Axis-Shield Diagnostics); the sensitivity obtained was 52.8%, 58.5% and 52.8%, respectively, with 100% specificity for all three kits. Anti-CCP...
Percentages of samples positive for IgG-, IgA- and IgM- anti-CCP2 antibodies and RhF and for 9G4 expression.Geraldine CambridgeRita A. MouraTania SantosAkif A. KhawajaJoaquim PolidoPereiraHelena CanhãoMaria J. LeandroJoão E. Fonseca