Lifestyle measures should form the foundation of cardiovascular risk control. Many pharmacological interventions targeting oxidation have proven disappointing. A large program tested inhibition of a LpPLA(2) (lipoprotein-associated phospholipase A(2)), culminating in 2 large-scale clinical trials that ...
In addition, a normal control group and an atherosclerotic group were used for comparison. All drugs were intragastrical administered once daily 10 mL/kg for 4 weeks. Body weight (BW), lipid profiles, C-reactive protein (CRP), vascular cell adhesion molecule-1 (VCAM-1), and intercellular ...
109 Treatment of ApoE deficient mice with GIP(1–42) prevents development of atherosclerotic lesions110 and attenuates cardiac hypertrophy and cardiac fibrosis induced by Angiotensin II.111 Ventricular injury following myocardial infarction is nonetheless reduced in GIPR deficient mice, and this coincides ...
Lindqvist et al.2009|Influence of herring | and herring fractions on metabolic status in rats fed a high energy diet JP4368523B2|2009-11-18|Anti-atherosclerotic and antithrombotic drugs and uses thereof Jacob1999|Evidence that diet modification reduces in vivo oxidant damage Frøyland et al.2011...
In addition, a normal control group and an atherosclerotic group were used for comparison. All drugs were intragastrical administered once daily 10 mL/kg for 4 weeks. Body weight (BW), lipid profiles, C-reactive protein (CRP), vascular cell adhesion molecule-1 (VCAM-1), and intercellular ...
Several of the sodiumゞlucose linked transporter 2 inhibitors (SGLT2is) and glucagon﹍ike peptide 1 receptor agonists (GLP1㏑As) dramatically improve outcomes of individuals with type 2 diabetes with and without chronic kidney disease, which is, as heart failure and atherosclerotic cardiovascular ...
2010), raising the question whether the efficacy of LDL-C lowering therapy in reduction of CHD events would be higher if initiated earlier in life based on the observational studies with a correlation of atherosclerotic lesions to plasma cholesterol levels with increasing lifetime (Strong and McGill...
Available evidence suggests that the consumption of edible insects may not only contribute protein and other valuable nutrients to the human diet but may also provide health benefits through various insect-derived peptides and bioactive compounds. Most studies of potential anti-obesity effects of edible...
In ApoE deficient mice, dabigatran reduced both sizes and progression of the atherosclerotic plaques, decreasing the inflammatory cells infiltration [109]. In a mouse model of diabetes [110], dabigatran has been found to decrease both endothelial dysfunction and the expression of MCP-1 and ICAM-1...
Lifestyle modification, including weight loss and exercise, are effective treatments for T2D, but, unfortunately, most patients are unsuccessful at maintaining durable weight reduction and recidivism is all too common. Therefore, safe and efficacious drugs are required for the successful treatment of ...