apoptosis; (4) Normal mature lymphocytes of PBMC could be induced to proliferate and /or to die from apoptosis when they were costimulated by anti-CD〓McAb and rIL-2. Both proliferation and apoptosis were existing in the same cultivation system sugsesting that the presence of rIL- 2 might ...
as well as subsequent integration of these macromolecules into nucleic acids, restricts tumour cell activity and causes apoptosis, or cell death. Most antimetabolites have a high cell cycle selectivity and can target cancer
several members from the B-cell lymphoma 2 (Bcl-2) protein family were amongst the top hits. Bcl-2 proteins are widely known for regulating apoptosis, as the binding of antiapoptotic Bcl-2 proteins to proapoptotic Bcl-2
Aim: To investigate the antiproliferative activity and apoptosis-inducing effects of bufalin on human osteosarcoma cell lines. Methods: U-2OS and U-2OS met... JQ Yin,JN Shen,SU Wei-Wei,... - 《Acta Pharmacologica Sinica》 被引量: 125发表: 2007年 加载更多来源...
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Laser scanning microscopic observations indicated that APRPGPEG-modified DPPCNDAC liposomes (LipCNDAC/APRPGPEG) colocalized with angiogenic vessels and strongly induced apoptosis of tumor cells, whereas PEG-modified DPPCNDAC liposomes (LipCNDAC/PEG) did not. In fact, LipCNDAC/APRPGPEG suppressed ...
During differentiation, apoptosis weeds out lymphocytes... VS Marsden,A Strasser - 《Annual Review of Immunology》 被引量: 752发表: 2003年 Bcl-2 complexed with Beclin-1 maintains full anti-apoptotic function (2009a). Why doesn’t Beclin 1, a BH3-only protein, suppress the anti-apoptotic ...
Further, LDMs can be non-specific, meaning that potential synergistic or antagonistic effects must be assessed. Within existing literature, there is contention surrounding the antimicrobial mechanisms of LDMs. This is due to the complexity of the system as a whole, with interrelated and often ...
However, 10–20% of advanced RCC patients are intrinsically refractory to sunitinib, and the remaining patients typically experience tumor progression after 6–15 months of therapy, meaning sunitinib fails to successfully prolong the survival of RCC patients13. Because RCC is difficult to completely ...