A vaccinated person's immune system would be trained to look for senescent cells and destroy them on sight; in contrast, someone taking senolytic drugs would need to take them repeatedly, as senescent cells would reaccumulate after each course of treatment, he said. To develop their senolytic ...
In cells pre-stimulated with LPS, GM1 treatment still decreased TNF and IL-1β gene expression (Fig. 1C), with an IC50 of 4.6 µM for TNF inhibition and 16.4 µM for IL-1β (Additional file 1: Fig. S1A) and decreased the amount of TNF released into the culture medium (Fig. ...
61. Veit Ny, Milan Houška, Roman Pavela, Jan Tříska,Potential benefits of incorporating Astragalus membranaceus into the diet of people undergoing disease treatment: An overview, Journal of Functional Foods,Link Here
‘anti-thymic stromal lymphopoietin monoclonal antibodies’, ‘anti-IL-33 monoclonal antibodies”, ‘anti-IL-17A monoclonal antibodies’, ‘matrix metalloproteinase inhibitors’, ‘neutrophil elastase inhibitors’, ‘α1-antitrypsin replacement therapy’, ‘treatment of cardiovascular diseases in COPD’ and...
in hormone receptor (HR) positive mature luminal cells leading to increased proliferation and thus accelerated mitotic ageing in HR negative luminal progenitor cells resulting in increased cancer risk; these effects are reduced after treatment with the progesterone antagonist mifepristone. HR, hormone ...
Increased lipid deposition also occurs in the cell cytoplasm of the zona glomerulosa, fasciculata or reticularis following treatment with drugs and other xenobiotics.1,120 Xenobiotics can increase lipid deposition in the adrenal cortex as part of a general cytotoxic phenomenon or through pharmacologically...
Depigmentation and anti-aging treatment by natural molecules Curr. Pharm. Des., 25 (20) (2019), pp. 2292-2312 CrossrefView in ScopusGoogle Scholar [4] N. Chondrogianni, S. Kapeta, I. Chinou, K. Vassilatou, I. Papassideri, E.S. Gonos Anti-ageing and rejuvenating effects of quercetin...
Since their discovery in the early 1970s, statins have become the mainstay treatment for patients with high cholesterol levels [238]. As research advanced, the use of statins expanded due to their anti-inflammatory properties where they have been shown to be effective in the management of corona...
In the August 2014 situation of Prevention, readers are alerted to a new anti-wrinkle collagen treatment that research demonstrates really functions as nicely as – if not greater than – most retinoic acid lotions. A lot more astonishingly is the reality that this anti-ageing … Read through ...
Transcriptome signature analysis repurposes trifluoperazine for the treatment of fragile X syndrome in mouse model. Commun Biol. 2020;3(1):127. Published 2020 Mar 16. View article Weiterer SS, Meier-Soelch J, Georgomanolis T, et al. Distinct IL-1α-responsive enhancers promote acute and ...