Models of chronic alcoholism in animals, used advantageously in the study of the pathogenesis of this illness, are not always satisfactory for screening antialcoholic drugs. It is therefore appropriate to consider the basic studies of this subject in developing the most efficient directions for ...
The core of alcoholism, like of any other type of addiction, is a mental dependence on alcohol. Alcohol negatively affectsindividual’s personality. An alcoholic is unable to control his behavior, he can’t keep the promises. Therefore it is absolutely necessary to quench desire for alcohol, ...
12including cocaine, opiates, marijuana and methamphetamine. Drug relapse observed for alcohol and other drugs is causally associated with the existence of high levels of extracellular glutamate, since the administration of N-acetyl cysteine or ceftriaxone which increase the level of the astrocyte Na-gl...
Ray, whose laboratory studies the causes of and possible treatments for drug and alcohol addiction, said testing new treatments for alcoholism is critical because the U.S. Food and Drug Administration has approved only four treatments for alcoholism, and they have been only modestly effective. Alt...
Exclusion criteria included being institutionalized, suffering from a physical or mental illness that would have limited their participation in physical fitness or their ability to respond to questionnaires, chronic alcoholism or drug addiction, and intake of drugs for clinical research over the past ...
As for other drugs, the reinstatement of alcohol-seeking induced by alcohol-associated cues was attenuated by SB-334867 treatment both immediately after extinction or following protracted Pharmaceuticals 2011, 4 809 abstinence, a model that may better mimic human alcoholism [49,57,58]. In addition...
Antimigraine drugs are medications used to prevent or lessen the intensity of migraine headaches, which are characterized by symptoms like nausea, vomiting, and sensitivity to light. These drugs include various types such as triptans, β-blockers, anticonvulsants, and others, aimed at treating acute...
Sherlock Holmes in the series by Arthur Conan Doyle: Holmes's exceptional deductive skills are coupled with his socially abrasive personality and addiction to drugs, painting him as an antihero. Dr. Frankenstein inFrankensteinby Mary Shelley: While he's the protagonist, Dr. Frankenstein, the creato...
Antifolate drugs are now routinely used for treating certain cancers “Folate is important for cells and tissues that rapidly divide.[25] Cancer cells divide rapidly, and drugs that interfere with folate metabolism are used to treat cancer. The antifolate methotrexate is a drug often used to treat...
Yet a recent review for the Agency for Healthcare Research and Quality estimated that less than a third of people who need treatment get it, and of those, less than 10 percent receive medications. Three drugs are approved by the Food and Drug Administration to treat alcohol abuse. One, nalt...