Murine macrophages have been classified as either susceptible or nonsusceptible to killing by anthrax lethal toxin (LT) depending upon genetic background. While considered resistant to LT killing, we found that bone marrow-derived macrophages (BMMs) from DBA/2, AKR, and C57BL/6 mice were slowly...
Anthrax lethal toxin (LT), produced by, comprises a receptor-binding moiety, protective antigen and the lethal factor (LF) protease. Although LF is known to cleave mitogen-activated protein kinase kinases (MEKs/MKKs) and some variants of the NLRP1 inflammasome sensor, targeting of these ...
Lethal toxin (LT) Protective antigen (PA) combines ET and LT, facilitating entry into cells and assisting in downregulating immune responses. B. anthracis antimicrobial resistance Many antibiotics appear useful with low MICs. High-level resistance may be seen for beta-lactams (both penicillins an...
网络释义 1. 炭疽致死毒素 炭疽毒素,anthrax... ... ) ATR 炭疽毒素受体 )anthrax lethal toxin炭疽致死毒素... www.dictall.com|基于3个网页 2. 是小鼠炭疽致死毒素 ... 炎症复合体 炭疽致死毒素( anthrax lethal toxin, LT) 功能性等位基因可能是小鼠炭疽致死毒素(anthrax lethal toxin, LT) ... ...
Anthrax toxins are composed of protective antigen (PA), which binds to ANTXR2, and the protein cargoes edema factor (EF) and lethal factor (LF). Intrathecal administration of edema toxin (ET (PA + EF)) targeted DRG neurons and induced analgesia in mice. ET inhibited mechanical and ...
Microarray analysis was used to investigate the effects of Bacillus anthracis lethal toxin (LT) on human neutrophil-like NB-4 cells to identify markers of intoxication. Genes down-regulated after a 2 h LT exposure included those encoding chemokines and transcription factors. Significant decreases in ...
B. anthracis produces two major toxins, lethal toxin (LT) and edema toxin (ET), which play essential roles in its virulence (Sweeney et al., 2010). As with many bacterial toxins, anthrax toxins are binary in structure, possessing a cell-binding, pore-forming subunit that gains entry into...
Anthrax lethal toxin (LT), a major virulence determinant of anthrax disease, induces vascular collapse in mice and rats. LT activates the Nlrp1 inflammasome in macrophages and dendritic cells, resulting in caspase-1 activation, IL-1β and IL-18 maturation and a rapid cell death (pyroptosis). ...
humans. The toxin produced by B. anthracis consists of two bipartite protein exotoxins, lethal toxin (LT) and edema toxin. LT is composed of protective antigen (PA) and lethal factor (LF), whereas edema toxin consists of PA and edema factor (EF). None of these three components, PA, LF...
Anthrax infection is associated with devastating cardiovascular sequelae, suggesting unfavorable cardiovascular effects of toxins originated from Bacillus anthracis namely lethal and edema toxins. This study was designed to examine the direct effect of l