Tai, S. et al. (2015) Cannabinoid withdrawal in mice: inverse agonist vs neutral antagonist. Psychopharmacology 232, 2751-2761Tai S, Nikas SP, Shukla VG, Vemuri K, Makriyannis A, Jarbe TUC. Cannabinoid withdrawal in mice: inverseTai, S., Nikas, S. P., Shukla, V. G., Vemuri, K...
www.nature.com/scientificreports OPEN S 38093, a histamine H3 antagonist/ inverse agonist, promotes hippocampal neurogenesis and received: 10 October 2016 accepted: 17 January 2017 Published: 20 February 2017 improves context discrimination task in aged mice Jean-Philippe Guilloux1,*, Benjamin A...
Recently, the medication discovery community has shifted research interest to CB1R neutral antagonists presuming that the inverse agonist profile of CB1R antagonists may underlie their unwanted side effects. We and others recently reported that CB1R neutral antagonists such as AM4113 offer attractive pro...
Inverse agonist and neutral antagonist actions of synthetic compounds at an insect 5-HT1 receptor. Troppmann B, Balfanz S, Baumann A, Blenau W (2010) Inverse agonist and neutral antagonist actions of synthetic compounds at an insect 5-HT1 receptor... B Troppmann,S Balfanz,A Baumann,... -...
5.Different form antagonist that blocks the effect of agonist, inverse agonist produces opposite effect to that of agonist.与阻断激动剂效应的拮抗剂不同,反向激动剂产生的效应与激动剂相反。 6.EFFECT OF CHOLINERGIC AGONIST AND ANTAGONIST ON PROLIFERATION AND DIFFERENTIATION OF CFU-GM IN VITRO胆碱能受体...
Williams, CEP-26401 (irdabisant), a potent and selective histamine H3 receptor antagonist/inverse agonist with cognition-enhancing and wake-promoting ... Robert,L.,Hudkins,... - 《Journal of Medicinal Chemistry》 被引量: 59发表: 2011年 3,4-Diaza-bicyclo[4.1.0]hept-4-en-2-one phenoxypro...
Effects of an intrathecally administered benzodiazepine receptor agonist, antagonist and inverse agonist on morphine-induced inhibition of a spinal nociceptive reflexdoi:10.1111/j.1476-5381.1988.tb11486.xFind more content: like this article Find more content written by:Jean-Luc MoreauLorenzo PieriAll ...
This agonist behaved thus like an inverse agonist on the constitutively active VPAC 1 receptors generated by C-terminal truncation and expressed in CHO cells. 展开 关键词: VPAC 1 receptor Inverse agonism Constitutive activity Truncated recombinant receptors ...
BF2.649 [1-{3-[3-(4-Chlorophenyl)propoxy]propyl}piperidine, hydrochloride], a nonimidazole inverse agonist/antagonist at the human histamine H3 receptor: Preclinical pharmacology. J Pharmacol Exp Ther 2007; 320: 365–375. Article CAS PubMed Google Scholar Lin JS, Dauvilliers Y, Arnulf I, ...
pharmaceutically acceptable compounds or histamine-113 receptor reverse osmosis, antagonist or inverse agonist, and disclosed preventive or medicament is a substance having an antagonistic effect on histamine binding to a histamine 113 receptor or an inhibitory effect on the activity of a receptor of his...