(5-7). Originally identified as a protein inhibitor of phospholipase A2, annexin A2 has subsequently been shown to interact with an array of protein and non-protein partners, including F-actin, spectrin, SNARE complexes, RNA, and virus particles (4,6,8,9). An...
Annexin A2, Annexin A2 heterotetramer, HIV-1, Inhibitor, Macrophage, ReceptorDuring sexual transmission of human immunodeficiency virus (HIV), macrophages are initial targets for HIV infection. Secretory leukocyte protease inhibitor (SLPI) has been shown to protect against HIV infection of macrophages ...
alternatively referred to as lipocortin, has been implicated as a mediator of the anti-inflammatory response produced by glucocorticoids and as an inhibitor of cPLA2, a potent mediator of inflammation. Annexin A2, also called p36, exists as a monomer or as a heterotetramer, complexed with the...
alternatively referred to as lipocortin, has been implicated as a mediator of the anti-inflammatory response produced by glucocorticoids and as an inhibitor of cPLA2, a potent mediator of inflammation. Annexin A2, also called p36, exists as a monomer or as a heterotetramer, complexed with the...
Cells were lysed with 1% Triton X-100 in TBS (50 mM Tris, 150 mM NaCl, pH 7.4) supplemented with protease inhibitor (cOmplete™, Roche). Post-nuclear lysates were incubated with 30 µl streptavidin-coupled sepharose beads (High Performance Streptavidin Sepharose, GE Healthcare) for...
bindingphosphatidylinositol-4,5-bisphosphate bindingcytoskeletal protein bindingRab GTPase bindingphospholipase A2 inhibitor activityreceptor activator activityS100 protein bindingpoly(A) RNA bindingcalcium-dependent protein bindingcadherin binding involved in cell-cell adhesionphospholipase inhibitor activitycalcium-...
Annexin A2 Antibody detects endogenous levels of total Annexin A2 Immunogen: A synthesized peptide derived from human Annexin A2 Description: Originally identified as a protein inhibitor of phospholipase A2, annexin A2 has subsequently been shown to interact with an array of protein and non-protein ...
In ANXA2−/− mice with vascular injury, an anti-B2GPI mAb caused formation of smaller thrombi than those in wild-type mice. Next steps could include developing anti-ANXA2 antibodies or small molecule inhibitors of the receptor. TransMolecular Inc. has TM601, an angiogenesis inhibitor ...
Annexin A2 is a cytoskeletal calcium-dependent phospholipid binding protein, which has been shown to be a mediator of corticosteroid activity, a substrate for serine/threonine kinases and growth regulated tyrosine kinases, and may play a role in secretion. Annexin A5 is a PKC inhibitor, directly ...
Primary structure of bovine calpactin I heavy chain (p36), a major cellular substrate for retroviral protein-tyrosine kinases: homology with the human phospholipase A2 inhibitor lipocortin Biochem., 25 (1986), pp. 4497-4503 CrossrefView in ScopusGoogle Scholar [33] U.K. Laemmli Cleavage of ...