Theankyrinrepeat-containing SOCS-box (ASB) family, the largest family ofCRL5substrate receptors, is composed of 18 members, ASB1∼18, which are characterized by the presence of two conserved domains, the N-terminal 4-12ankyrin repeatand the C-terminal SOCS-box domain (Fig. 3). The ankyri...
New designed ankyrin repeat domains with binding specificity for serum albumin, recombinant binding proteins comprising at least two designed ankyrin repeat domains with binding specificity for serum albumin, as well as recombinant binding proteins comprising at least one designed ankyrin repeat domain with...
Besides the conserved ankyrin-repeat and coiled-coil domains, there was a conserved motif at the N-terminal (KN motif) containing potential motifs for nuclear localization and export signals. Gene expression of these genes was examined by RT-PCR at the mRNA level and by Western blotting and ...
Here we report a fragment-based screening programme against tankyrase ARC domains, using a combination of biophysical assays, including differential scanning fluorimetry (DSF) and nuclear magnetic resonance (NMR) spectroscopy. We identify fragment molecules that will serve as starting points for the ...
The ankyrin domain is one of the most common protein motifs in eukaryotic proteins. Repeated ankyrin domains are ubiquitous and their mediation of protein–protein interactions is involved in a number of physiological and developmental responses such as the cell cycle, signal transduction and cell diff...
英文名称:SH3 And Multiple Ankyrin Repeat Domains Protein 3 (SHANK3) Antibody (ATTO 680),中文名称:SH3和多个锚蛋白重复结构域蛋白3(SHANK3)抗体(ATTO 680),产品货号:Catalogue No: abx441824,SHANK3抗体是一种针对SHANK3的小鼠单克隆抗体。靶
The TN1 gene encodes an ANK family protein containing nine ANK domains and four transmembrane domains (Fig. 2e). The N-terminal region of TN1 contains nine ANK domains based on the SMART protein prediction program (http://smart.embl-heidelberg.de/), and the C-terminal region contains four ...
SH3 and multiple ankyrin repeat domains 3March in sports
Protein truncation series demonstrated that both proteins interact through their ankyrin domains. Using reverse genetics, we showed that loss of akr function resulted in an embryo-defective ( emb ) phenotype indistinguishable from the emb506 phenotype. Transient expression of the signal peptide of AKRP...
It is likely that the highly dynamic nature of the N- and C-terminal SNARE domains prevents stable packing of the two proteins. Indeed, the crystal structure of ANK17 bound to Snap25b111-120 agrees with this hypothesis. The structure shows that the critical part of the interaction is ...