The development and production cycle of the mRNA vaccine is shorter than that of traditional vaccines. A number of research institutes and companies around the world are stepping up efforts in developing vaccines and agents against the novel coronavirus, which has already caused 40,171 confirmed case...
dubbed mRNA-1273. The vaccine quickly moved toPhase II trials, although the results are not published yet (you can follow the progress of COVID-19 vaccines with theNew York Times Coronavirus Vaccine Tracker, which importantly also highlights preclinical ...
Reports of DNA vaccines previously developed to treat VHSV, have been controversial and costly, affecting the industry and consumer appeal. Lipid nanoparti- cles (LNPs) encapsulating small-interfering RNAs (siRNAs) is being proposed here as a potential thera- peutic approach to treat VHSV. In ...
Animal models are vital for studying pathogenic mechanisms, the induction of immune response, immune escape mechanisms, antiviral drugs, and vaccines against SARS-CoV-2. In-depth research on SARS-CoV-2 requires appropriate animal models. Therefore, in this review, we primarily summarize the current ...
such as mRNA vaccines (mRNA-1273), adenoviral vector vaccines (ChAdOx1 nCoV-19 and Ad5-nCoV), recombinant subunit vaccines (NVX-CoV2373 and RBD-Fc-based COVID-19), and inactivated vaccines (BBIBP-CorV and PiCoVacc), have been tested in mice. These vaccine candidates provided mice with pr...
VACCINE trialsMICROCIRCULATION disordersRNAVACCINESCOMPOSITION of breast milkEMERGING infectious diseasesHERD immunityExplosive developments in mRNA vaccine technology in the last decade have made it possible to achieve great success in clinical trials of mRNA vaccines to prevent infectious diseases and develop...
The recent development of mRNA vaccines against SARS-CoV-2 is rapidly opening a new avenue for vaccines against infectious diseases, and an exploration of the combination of EV and RNA vaccination approaches is warranted. Author Contributions S.M.-T., L.F., M.M. and H.D.P. contributed ...
showing how well the vaccine works in virus-susceptible animals, but when asked whether they would, Graham replied, “Safety and product integrity are the primary criteria for starting a Phase 1 trial and mRNA has now been used in several clinical trials and shown to be saf...
These mRNA vaccine candidates demonstrated strong humoral immunity, primed effector T cells, and significant reduction in diarrhea duration and viral shedding. These promising results provide proof of concept for further development of mRNA vaccines against rotavirus infections (Hensley et al., 2024). ...
COVID-19: An overview of the current pharmacological interventions, vaccines, and clinical trials 2Virology Coronaviruses (derived from the Latin word corona, meaning crown) are positive sense, single-stranded envelopedRNA viruseswith a diameter of 60 nm to 140 nm, and are widely dispersed in na...