Animal Models and Experimental Medicine(简称AMEM,《动物模型与实验医学(英文)》)是国际化,开放获取的英文期刊,由中国实验动物学会和中国医学科学院医学实验动物研究所共同主办,与国际著名出版集团Wiley合作出版,为双月刊。期刊已陆续被ESCI、M...
The use of animal models of human disease is critical for furthering our understanding of disease mechanisms, for the discovery of novel targets for treatment, and for translational research. This Special Topic entitled "Animal Models of Human Disease" aimed to collect state-of-the-art primary ...
Murine models of renal disease: possibilities and problems in studies using mutant mice. The elucidation of the pathogenesis of human renal disease at the molecular level has been facilitated by the growing field of gene targeting and the devel... HJ Anders,Schlö,D Ndorff - 《Experimental Ne...
to individualized patient care. In this perspective, we used subgroups of specific ALS-linked gene mutations to go through existing animal models and to provide a comprehensive profile of the differences and similarities between animal models of disease and human disease. Finally, we reviewed applicati...
Transcriptome analysis of AAV-induced retinopathy models expressing human VEGF, TNF-α, and IL-6 in murine eyes Kolja Becker , Carina M. Weigelt & Norbert H. Redemann Article 11 November 2022 | Open Access Oxidative stress mediates end-organ damage in a novel model of acetaminophen-toxi...
Chapter 30 - Animal Models: Systemic Autoimmune Diseases Although animal modes do not represent with fidelity human disease, they have provided significant insights into the abrogation of self tolerance, the ... M Mizui,GC Tsokos - Elsevier Inc. 被引量: 2发表: 2014年 Targeting the Main Anatomo...
This chapter introduces the subject of animal models both spontaneous and induced models, used in different human disease studies. The benefits of animal models are that one can study the mechanisms of diseases as well as test new and emerging drugs for their therapeutic efficacy. Rheumatoid arthrit...
Multiple animal models were generated to mimic the disease and to test future treatments. However, no animal model fully replicates the spectrum of phenotypes in the human disease and it is difficult to assess how a therapeutic effect in disease models can predict efficacy in humans. Importantly,...
Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information...
Modelling human liver disease: from steatotic liver disease to MASH-HCC Having more refined mouse models of metabolic dysfunction-associated steatotic liver disease (MASLD; also known as nonalcoholic fatty liver disease) will help to advance research into this disease. In their study, Jeong and co...