Moreover, animal models of atherosclerosis are pivotal for testing mechanistic hypothesis and for translational research, including the assessment of dietary and/or pharmacological interventions and the development of imaging technologies and interventional devices. In this chapter, we will describe the most...
In general, animal models of atherosclerosis are based on accelerated plaque formation due to a cholesterol-rich/Western-type diet, manipulation of genes involved in the cholesterol metabolism, and the introduction of additional risk factors for atherosclerosis. Mouse and rabbit models have been mostly...
Elisabeth Uitz, Babak Bahadori,Karl Landsteiner Private University of Health and Life Sciences, State Clinic St. Poelten, Department of Internal Medicine 2, 3100, St. Poelten, Austria Abstract In this mini-review several commonly used animal models of atherosclerosis have been discussed. Among them,...
as atherosclerosis was not then recognized as a major disease. However, the increasing prevalence of cardiovascular disorders within the global burden of disease2has given the desire to understand and
were evaluated for their usefulness in research on atherosclerosis. When the monkeys were given diets containing 1 mg cholesterol/kcal serum cholesterol increased from control value of about 200 to about 290 mg/100 ml. Control and test monkeys had aortic fatty streaks and occasional lesions of the...
Antibodies (Ab) which block the binding of CD47 to its cognate receptor SIRPα potently reduce plaque vulnerability and lesion size by preventing the accumulation of apoptotic debris in murine models of atherosclerosis6. These pre-clinical observations were recently extended in a phase I trial of th...
Table 1.Animal models of atherosclerosis: advantages and limitations. Mouse(i) Rapid development of atherosclerotic plaques(i) Only partial resemblance to humans (ii) Short reproductive cycle(ii) More atherosclerotic than atherothrombosis model
Animal models have significantly advanced the understanding of mechanisms involved in atherosclerosis and restenosis and have allowed the evaluation of therapeutic options. The current focus of research is to develop strategies to prevent restenosis. These include pharmacological and biological interventions dir...
Animal Models of AtherosclerosisAuthor links open overlay panelDaniel Steinberg M.D., Ph.D.Show more Add to Mendeley Share Cite https://doi.org/10.1016/B978-012373979-7/50034-0Get rights and contentAccess through your organization Check access to the full text by signing in through your ...
ANIMAL MODELS OF DISEASE LIPID DISORDERS AND ATHEROSCLEROSIS IN GENETICALLY MODIFIED MICE It is now generally accepted that the lesions of atherosclerosis begin as a result of some form of insult to the lining endothelial and smooth muscle cells of the artery wall. This insult can relatively rapidly...