Animal models in myopia research. Clin Exp Optom. 2015;98:507-517.Schaeffel F, Feldkaemper M. Animal models in myopia research. Clin Exp Optom 2015; 98:507-17. [PMID: 26769177].Schaeffel, F. & Feldkaemper, M. Animal models in myopia research. Clinical and Experimental Optometry 98, ...
2. Experimental models for myopia The general structure of the eye, the role of photopic vision in emmetropization, and the visual signaling circuitry, as well as the types and patterning of retinal neurons, are highly conserved among vertebrates, making it possible to simulate human myopia in ...
In Figure 3 the genes associated with POAG in general, NTG, and high-tension glaucoma (HTG) are shown. Common variants associated with POAG endophenotypes Research of endophenotypes has been a successful strategy to elucidate the genetics of POAG. Eye Genes, pathways, and animal models in POAG ...
Due to their genetic similarity to humans and the availability of tools for population genetics, numerous models based on tree shrews have been thoroughly explored in studying myopia,25,26,27 hepatitis virus infections,28,29 depression,30 aging,31 learning behaviors as well as social stress.32 ...
Table 1.Summary of the animal models commonly used for glaucoma research. TM: trabecular meshwork; PAS: peripheral anterior synechiae; RGC: retinal ganglion cell. 1.1.1. Monkeys Glaucoma in monkeys was first described in 1993, when a group of rhesus monkeys at the Cayo Santiago monkey colony ...
Mouse models ofRing1b(mouse orthologue ofRNF2) highlight the importance of RING1B and its catalytic activity during mouse embryogenesis. InRing1b-KOmice, embryonic lethality occurs prior to E10 (Voncken et al.2003). The catalytic hypomorphRing1bp.I53A (Ring1bI53A) mouse allele expresses a...
Although elevated intraocular pressure (IOP) remains the major risk factor in glaucoma, neurodegenerative processes continue despite effective IOP lowering. Altered α-synuclein antibody (Abs) levels have been reported to play a crucial role. This study
Besides its apparent efficacy in slowing myopia in children, atropine inhibits myopia development not only in tree shrew and monkey myopia models (McKanna and Casagrande, 1981;Raviola and Wiesel, 1985;Tiggeset al., 1999), but it also blocks form deprivation myopia or lens induced myopia in chi...
When viewing the fundus of affected animals, it is necessary to interpose biconcave lenses in order to see the retinal vessels clearly. The functional effect would be a tendency toward myopia (58). The lens changes were first observed in dogs receiving 5 g DMSO/kg after 9 weeks of ...
In humans, ADAMTS17 mutations are known to cause Weill-Marchesani-like syndrome, which is characterised by lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature. Breed-specific homozygous mutations in ADAMTS17 are associated with p