To accomplish this, we need robust animal models that incorporate the same level of genetic and genomic variation as highly diverse human populations. A key goal of biomedical research is to provide clinicians with sufficient knowledge to predict disease risk and choose effective treatment. We are ...
humanized mouse models have become increasingly important in biomedical research because they can express human genes or harbor human tissues, making them better suited for studying diseases that have specific human pathophysiological characteristics, such as cancer, infectious diseases...
ANIMAL models in researchVACCINESIMMUNIZATIONPARASITIC diseasesCOMMUNICABLE diseasesANIMAL models of immunologyMEDICAL experimentation on humansImmunology and Cell Biology focuses on the general functioning of the immune system in its broadest sense, with a particular emphasis on its cell biology. Areas that ...
concerns surrounding ethics, expenses, and inherent species differences have catalyzed the exploration of alternative avenues. The contemporary alternatives to traditional animal models in biomedical research delve into three main categories of alternative approaches: in vitro...
Here, we describe each of the animal models and the type of OI they represent, and present their application in clinical research for treatments of OI, such as drug therapies (ie, bisphosphonates and sclerostin) and mechanical (ie, vibrational) loading. In the future, different dosages and ...
The success of preclinical stroke research in developing new therapeutics might rely – at least in part – on the selection of the appropriate animal stroke model to use. This review deals with the most common rodent stroke models and also discusses the advantages and limitations of each model,...
Although it may never be possible for a single animal model to recapitulate all of the features of HIV-1 infection of humans, there have been great advances in the development of small-animal and non-human primate models, as well as in the development of
摘要: Puget Sound Blood Center Research Institute, Seattle, Washington; Laboratory of Transfusion Biology, Department of Pathology and Cell Biology, Columbia University Medical Center, New York Presbyterian Hospital, New York, New York.关键词:
Like other domains of medical research, vision research focuses on the study of disease pathogenesis and the discovery of new therapies for the eye, using both in vitro and in vivo strategies. In vivo experiments involve animal models, including vertebrates (rodents, rabbits, primates, pigs, fe...
Organ-on-a-chip and 3D printing as preclinical models for medical research and practice Introduction An ultimate quest of mostbiomedical researchis to determine the basic communication between cells and molecules, which assemble to form human tissues and organs. The expectation is that with this know...