This chapter describes the use of animal models in behavioral pharmacology. Animal models are used throughout the biological sciences to provide complex systems for the study of complex problems. While animal studies are often conducted in lieu of or prior to human studies, in other instances an ...
An abuse potential assessment requires an understanding of all properties of a drug predictive of the abuse of the drug, and this multidisciplinary approach ranges from animal pharmacology through human pharmacology studies to postmarketing surveillance. ...
Animal models of obsessive-compulsive disorder: Exploring pharmacology and neural substrates 来自 NCBI 喜欢 0 阅读量: 60 作者:N Albelda,D Joel 摘要: During the last 30 years there have been many attempts to develop animal models of obsessive-compulsive disorder (OCD). Most models have not been...
Evaluation of a basic physiologically based pharmacokinetic model for simulating the first-time-in-animal study[J] . Massimiliano Germani,Patrizia Crivori,... M Ikeda,H Furukawa,H Imamura,... - 《Cancer Chemotherapy & Pharmacology》 被引量: 58发表: 2002年 Pharmacokinetic study of S-1, a nov...
Preclinical studies using an isolated, perfused rat-kidney model suggested that CLO may be a substrate of OCT2, a c... MC Foster,C Walko,P Kumar,... - 《Cancer Research》 被引量: 0发表: 2012年 加载更多来源期刊 Methods & Findings in Experimental & Clinical Pharmacology 1985年 研究点...
The zebrafish (Danio rerio) has become known as an excellent model organism for studies of vertebrate biology, vertebrate genetics, embryonal development, diseases and drug screening. Nevertheless, there is still lack of detailed reports about usage of the zebrafish as a model in veterinary medicine...
However, different POF animal model methods have their advantages and disadvantages. For example, the stability of POF animal models of autoimmune and mental stress is low. GAL-induced animal model can better simulate the physiological aging characteristics of clinical POF patients, but the success ...
We are the leading biotechnology company, which to provide professional lab animal(mice)model services including animal model development, breeding and analysis.
RA Morin,WH Lyness - 《Pharmacology Biochemistry & Behavior》 被引量: 25发表: 1983年 Potentiation of methotrexate-induced gastrointestinal toxicity by non-steroidal anti-inflammatory drugs (NSAIDs) and vincristine Inhibition of intestinal nutrient absorption by the folate antagonist methotrexate (MTX) an...
All or none for certain pharmacology principles 2 No or not shown 1 This scoring system uses five different criteria: This scoring system can help to assemble a screening cascade/combination of models which altogether has maximal validity. For example, the neonatal lamb model for RSV infection sco...