Further, individual human datasets were also compared with the models. Given that a basis for drug repurposing is a reversal of gene expression patterns in a given disorder, the identification of animal models with high congruence with humans at the large-scale gene expression level could provide ...
A comparison of rabbit and human skin response to certain irritants The relative irritancy of 12 varying chemical structures was compared in man and rabbit utilizing a variation of the standard Draize rabbit irritancy test. Tests were performed on men's forearms, and 21-day occlusive and open ...
The era of molecular cytogenetics, which persists to this day, began about 1977. With improved methods for studying DNA, the biochemical basis of banding was elucidated. The GC-rich nature of the Giemsa-light bands was demonstrated, and this information was correlated with evidence that these ba...
Drosophila melanogasteris a useful tool for genetics research given its low maintenance cost as compared to rodents and other mammals. It also has shorter lifespan which allows for fast initial studies of diseases and treatment. However, the mammalian nervous system is much more complex and addition...
Synanthropic behavior, i.e., the behavior of wild animals that benefit from a shared ecology with humans, has existed long before the sedentarization of Ho
we explored whether a DNA signal consistent with interspecies hybridization was apparent within the CR macaque and CE macaque genomes. We calculated the divergence ratio between the CE macaque and CR macaque and compared it with the divergence ratio between the CR macaque and IR macaque for 50-kb...
(decoding) of the message into protein in the cytoplasm. Compared to the structure of the bacterialcell, this gives greater control over which proteins are produced. Such control permits specialization of cells, each with identical DNA but with the ability to control finely which genes successfully...
Toxicology Studies – non-clinical data to demonstrate the investigational drug has the expected pharmacologic activity, is reasonably safe for initial testing in humans. c. Manufacturing Information As described in earlier sections, the IND contains three broad areas of information: Animal Pharmacology,...
When the phylogenetic characteristics of the gut microbiota in each host were compared based on the average unweighted UniFrac distance, the human gut microbiota was found to be significantly different from that of all other animals. The microbiota in chicken fecal matter exhibited the greatest ...
Despite the study of immunology in fish being more recent compared to those of humans and in animals, the concepts and techniques used are similar [60]. The study of the use of vaccines in fish is an area of fast-growing. As aquaculture expands and the need to control pathogens becomes ...