“designed and based on the results of animal experimentation [author’s italics] and a knowledge of the natural history of the disease.” The statement was written by Andrew Ivy, a strong proponent of animal research, but was not based on scientific evidence that such a requirement would ...
Between the ninth congress in Rio de Janeiro and the 10th in Vienna in 2001 (G. Utermann, president), database “mining” (research in silico or cybergenomics) came in as a primary method of genomic research. As a result of positional cloning and related approaches to disease gene discover...
Primaril... JB Sharefkin,C Lather,M Smith,... - 《Journal of Biomedical Materials Research》 被引量: 130发表: 1983年 Prediction of clinical response based on pharmacokinetic/pharmacodynamic models of 5-hydroxytryptamine reuptake inhibitors in mice Bridging the gap between preclinical research and ...
where the dot denotes the derivative with regard to time,mis the animal’s mass, andF1, …Fnare various forces acting on the animal. In this paper, we mostly focus on animals moving within viscous media such as air or water. In this case, the forces acting on the moving animal include...
and disease. In this review, we highlight the key proteomics technologies, methodologies, and their applications in domestic animals, particularly in the tropical context. We also discuss advances in proteomics research, including integration of multi-omics data, single-cell proteomics, and proteogenomi...
New abnormal social behaviour patterns from animal disease models cannot be covered by existing behavioural classification datasets. Some subsecond behaviours are casually ignored in labelling because they are too short13. This means supervised behaviour classification methods are not suitable for detecting ...
Animal models have historically been utilized for the prediction of human responses to drugs and disease and this use has also been the justification for animal use in research in general [118,119]. But because various levels of organization and different modules can be acted on by the same pe...
Afterward, one critical issue for phenotypic prediction is how to model non-additive effects (dominance or epistatic effects). Several research confirmed that using non-additive relationships that could improve the prediction of phenotypes [18,19]. Incorporating additional layers of omics data into the...
While livestock associated disease is a clear threat to sustainability, improving animal health also represents a pathway towards more sustainable livestock systems. The overall burden of animal disease is not accurately quantified, but there is little doubt that it is both enormous and largely borne ...
Neurobehavioral disorders and developmental origins of health and disease. In The Epigenome and Developmental Origins of Health and Disease; Elsevier: Amsterdam, The Netherlands, 2016; pp. 235–266. [Google Scholar] Field, T.; Diego, M.; Dieter, J.; Hernandez-Reif, M.; Schanberg, S.; ...