Using a logistic regression model, 3-fold cross-validation (CV), the number of CV repeats as 3, and top biomarker proportion as 0.05, we identified an 8-genus biomarker for TB classification. Then we tested the biomarker performance by using only the 8-genus biomarker for cross-validation, ...
3.Maron BJ, Towbin JA, Thiene G, Antzelevitch C, Corrado D, Arnett D, et al. Contemporary definitions and classification of the cardiomyopathies: An American heart association scientific statement from the council on clinical cardiology, heart failure and transplantation committee; quality of ca...
Caton JG, Armitage G, Berglundh T, Chapple ILC, Jepsen S, Kornman KS, et al. A new classification scheme for periodontal and peri-implant diseases and conditions—introduction and key changes from the 1999 classification. J Periodontol. 2018;89(Suppl 1):S1–8. https://doi.org/10.1002/J...
d The acyltransferase (AT) domain sequence indicates loading preference for methymalonate while the e enoylreductase (ER) domain lacks key NADPH binding site residues making this function inactive. Full size image Like other type I FAS and PKS enzymes, EcPKS1 and EcPKS2 contain multiple domains...
By the tenth generation of breeding, we could predict with over 95% certainty the classification of our animals as high or low responders based on their selectively bred line (see Supplementary Figure 1). With each generation of breeding, the phenotypic differences in reactivity to novelty have ...
Hyperglycemia, a condition characterized by high level of glucose in the blood is a characteristic feature of both type 1 and type 2 diabetes. Because of its subtle and chronic nature, the hyperglycemia plays a key role in the development of diabetic complications [134]. The complications associa...
The clustered regularly interspaced short palindromic repeats (CRISPR) and their associated protein (Cas) system is a gene editing technology guided by RNA endonuclease. The CRISPR-Cas12a (also known as CRISPR-Cpf1) system is extensively utilized in genome editing research due to its accuracy and ...
The age-of-onset and severity of the disease varies widely, leading to a historical classification of SMA into three distinct subtypes, Type I (Werdnig-Hoffman disease, early infantile onset), Type II (intermediate late infant onset), and Type III (Kugelberg-Welander, childhood onset) [5, ...
In the past two decades, over-prescription of opioids for pain management has driven a steep increase in opioid use disorder (OUD) and death by overdose, exerting a dramatic toll on western countries. OUD is a chronic relapsing disease associated with a
Classification of Cerebellar Ataxias Cerebellar ataxias represent a heterogeneous group of disorders characterized by a lack of coordination and imbalance [3,4]. Patients exhibit various combinations of oculomotor deficits, dysarthria, dysmetria, and kinetic tremor. Various forms of learning are impaired...