A labeled diagram of an animal cell, and a glossary of animal cell terms. Learn about the different parts of a cell.
SWNTs preferentially accumulate in the early atherosclerotic lesion and SHP1 inhibition reduces apoptotic cell accumulation in addition to vascular inflammation in vivo To determine the impact of pro-efferocytic therapies on vascular disease in a large animal model, we randomized 3-month-old LDLR−...
Autophagy is the catabolic process that degrades cytoplasmic material via the lysosome. The process of macroautophagy was originally characterized in yeast, where the core autophagy-related proteins (ATGs) were identified. In this system, the multistep process of phagophore initiation and elongation ...
Autophagy is the catabolic process that degrades cytoplasmic material via the lysosome. The process of macroautophagy was originally characterized in yeast, where the core autophagy-related proteins (ATGs) were identified. In this system, the multistep process of phagophore initiation and elongation ...
Thus, lysosomes possess a remarkable versatility to sense and respond to metabolic shifts in the cell and are uniquely equipped to recalibrate cellular homeostasis on demand. But whether alternative mechanisms, in addition to increased biogenesis, can modulate lysosome activity in response to nutrient ...
Therefore, we sought to utilize PLGA NPs loaded with p16ink4a siRNA to rejuvenate aged microglia through cell cycle regulation in the 5XFAD mouse model of AD, thereby upregulating phagocytosis by microglial-specific siRNA. Materials and methods...
Crystal structures of SAPN/VLPS scaffolds. Natural self-assembled protein nanoparticles, rationally designed self-assembled protein nanoparticles, animal virus-derived VLPs, bacteriophage-derived VLPs, and plant virus-derived VLPs are labeled in black, blue, red, purple, and green, respectively. NP str...
However, LGG-1 pro- motes apoptotic-cell phosphatidylserine (PS) exposure, while LGG-2 mediates phagosome-lysosome interactions. Unlike mouse embryoid bodies (EBs) and chick retina (discussed below), autophagy gene mutations fail to impair PS exposure in C. elegans embryonic cell corpses [52]. ...
A similar uptake distribution is observed using fluorescently labeled, heat-killed E. coli cells, confirming the physiological relevance of BSA-coated bead experiments (Figures S1G–S1G″). Interested to explore whether endocytosed microspheres become mobilized, we used a 4-h incubation pulse of 20...
Yeast as a model system for studying endocytosis Exp. Cell Res., 271 (2001), pp. 1-9 View PDFView articleView in ScopusGoogle Scholar [63] B. Wendland, S.D. Emr, H. Riezman Protein traffic in the yeast endocytic and vacuolar protein sorting pathways Curr. Opi. Cell Biol., 10 (19...