Three-component synthesis of 4-aminoquinolines 72 was achieved from a two-stage imidoylative Sonogashira coupling from 2-bromoanilines 70 and arylacetylenes 71 followed by acid-mediated cyclizations (18JOC854). Niobium pentachloride was employed as a multifunctional reagent for the preparation of 2-...
N-Secondary o-aminophenylarylphosphinates were prepared by Pd-catalyzed cross coupling of aryl-P(OEt)(2) with the corresponding o-bromoanilines and reduced with LiAlH4 to o-phosphanylanilines. For the N-mesityl compounds a two-step reduction was necessary because of competing P-N condensation ...
N-Secondary o-aminophenylarylphosphinates were prepared by Pd-catalyzed cross coupling of aryl-P(OEt)(2) with the corresponding o-bromoanilines and reduced with LiAlH4 to o-phosphanylanilines. For the N-mesityl compounds a two-step reduction was necessary because of competing P-N condensation ...