Angiotensin II receptor blockers (ARB) have cardioprotective effects. However, it remains unclear whether miR-21 was involved in the mechanism of cardiac fibrosis with DN by target MMP-9 and ARB ameliorates cardiac fibrosis partly by inhibiting miR-21 expression. In this study, In Situ ...
Angiotensin II type 1 (AT 1 ) receptor blockers, such as candesartan, are attractive alternatives to ACE inhibitors in the treatment of hypertension and cardiovascular disease. Although angiotensin-converting enzyme (ACE) inhibitors are able to suppress the renin-angiotensin system (RAS), their ...
Most of the effects of Ang II are dependent on the stimulation of its AT1 receptors (Saavedra et al, 2006), and AT1 receptor overactivity promotes peripheral vascular and tissue inflammation (Savoia and Schiffrin, 2007). AT1 receptor blockers (ARBs) not only antagonize the Ang II-mediated ...
the release of VEGF, and the protective effects of angiotensin II antagonist against diabetic glomerular injury suggest that the angiotensin II-induced VEGF is an important pathogenetic mechanism in the development of proteinuria during diabetic nephropathy although this mechanism is not fully understood. ...
Therapeutic role of angiotensin II receptor blockers in the treatment of heart failure. Angiotensin II type 1 receptor blockers (ARBs) are generally as effective as angiotensin-converting enzyme (ACE) inhibitors in patients with hypertension. ... P Manohar,IL Pi?A - 《Mayo Clinic Proceedings》...
Angiotensin II Receptor Blockers and Neuropathy Trials.Focuses on topics related to angiotensin II receptor blockers and nephropathy, discussed during the American Diabetes Association 61st Scientific Sessions held in Philadelphia, Pennsylvania in June 2001. Mediators of vasolidation; Antihypertensive ...
Yukio Tominaga3, Yoshino Matsuo1, Sadashiva S Karnik2 and Keijiro Saku1 Angiotensin II (Ang II) type 1 (AT1) receptor blockers (ARBs) induce multiple pharmacological beneficial effects, but not all ARBs have the same effects and the molecular mechanisms underlying their actions are not certain...
In this study, we examined the effects of an AT1 receptor blocker on myocardial capillary density and cardiac ischemia in Dahl salt-sensitive hypertensive rats (DS rats) to elucidate the novel mechanism of angiotensin II-induced cardiac injury. Dahl salt- sensitive rat is a useful model for ...
OBJECTIVE: Angiotensin II type 1 receptor (AT1) blockers (ARBs) reduce the bacterial endotoxin lipopolysaccharide (LPS)-induced innate immune response in h... T Pang,J Benicky,J Wang,... - 《Journal of Hypertension》 被引量: 74发表: 2012年 Inhibitors of ATP-Binding Cassette Transporters Su...
It is widely assumed that Ang-II facilitates the growth of both cells, and its receptor blockers (ARBs) have the potential to inhibit the growth of various cancer cells and tumors through the Ang-II receptor type 1 (AT1 receptor). The mechanism of cell growth inhibition by ARBs has been...