Angiotensin II type 2 receptor agonists: where should they be applied? Expert Opin Investig Drugs 21: 501-513, 2012.K. Verdonk, A. H. Danser, and J. H. van Esch, "Angiotensin II type 2 receptor agonists: where should they be applied?" Expert Opinion on Investigational Drugs, vol. 21...
Keywords: Renal proximal tubular epithelial cells; Adiponectin receptor; Angiotensin II receptor; Dimerization 2 Introduction It is generally accepted that receptors, including G protein-coupled receptors (GPCRs), function as dimers or oligomers [1]. Indeed, evidence of homodimers and heterodimers has ...
The mechanisms of regulation, activation and signal transduction of the angiotensin II (Ang II) type 1 (AT1) receptor have been studied extensively in the decade after its cloning. The AT1 receptor is a major component of the renin-angiotensin system (RAS). It mediates the classical biological...
Conversely, activation of the angiotensin II type 2 receptor (AT2R) causes dilatation of blood vessels and inhibition of inflammation and fibrosis and is considered to be counter-regulatory to the negative effects of AT1R activation [13,14]. Natural ligands/agonists of AT2R such as Ang 1-7 ...
Angiotensin II has two major G protein-coupled receptor subtypes, the angiotensin II type 1 receptor (AT1R) and the angiotensin II type 2 receptor (AT2R)7. It is well recognized that angiotensin II acts as a powerful pro-inflammatory mediator through the stimulation of AT1R and subsequent ...
Access Advances in the allostery of angiotensin II type 1 receptor Xi Zhang1,2, Suli Zhang1,2, Meili Wang1,2, Hao Chen1,2 and Huirong Liu1,2,3* Abstract Angiotensin II type 1 receptor (AT1R) is a promising therapeutic target for cardiovascular diseases....
A substantial increase in [125I]Sar1,Ile8-Angiotensin II binding activity can be observed 24 hours after treatment of R3T3 cells with AT2receptor agonists and antagonists. An increase in the radioligand binding activity, although less profound, can also be observed 6 hours after AT2receptor ligan...
The angiotensin II (AngII) type 1 (AT1) receptor is a seven-transmembrane G-protein-coupled receptor that plays a regulatory role in the physiological and pathological processes of the cardiovascular system. AT1 receptor inherently shows constitutive activity even in the absence of AngII, and it is...
Wu et al, "Selective Angiotensin II AT2 Receptor Agonists," J. Med. Chem. (2006), Vol 49, pp. 7160-7168. REINECKE, K. et al., "Angiotensin H Accelerates Functional Recovery in the Rat Sciatic Nerve In Vivo: Role of the AT2 Receptor and the Transcription Factor NF-KB1,'' FASEB J...
This invention relates to compounds represented by formula I: ##STR1## which are agonists of angiotensin II. The invention is also concerned with the use of aforementioned agonists in the treatment of