Angiotensin II type 2 receptor agonists: where should they be applied? Expert Opin Investig Drugs 21: 501-513, 2012.K. Verdonk, A. H. Danser, and J. H. van Esch, "Angiotensin II type 2 receptor agonists: where should they be applied?" Expert Opinion on Investigational Drugs, vol. 21...
Angiotensin II is recognized to have proapoptotic properties30 and thus presents a plausible role for the RAS in the pathogenesis of diabetic heart disease. Specific blockade of the RAS with ACEIs and angiotensin receptor blockers (ARBs), for example, may attenuate some of these effects. Third,...
Angiotensin II has two major G protein-coupled receptor subtypes, the angiotensin II type 1 receptor (AT1R) and the angiotensin II type 2 receptor (AT2R)7. It is well recognized that angiotensin II acts as a powerful pro-inflammatory mediator through the stimulation of AT1R and subsequent ...
The mechanisms of regulation, activation and signal transduction of the angiotensin II (Ang II) type 1 (AT1) receptor have been studied extensively in the decade after its cloning. The AT1 receptor is a major component of the renin-angiotensin system (RAS). It mediates the classical biological...
Conversely, activation of the angiotensin II type 2 receptor (AT2R) causes dilatation of blood vessels and inhibition of inflammation and fibrosis and is considered to be counter-regulatory to the negative effects of AT1R activation [13,14]. Natural ligands/agonists of AT2R such as Ang 1-7 ...
(ACE) activity, the subsequent production ofangiotensin II. The latter exerts its function of main biological effector of the system through thetype 1 angiotensin receptor(AT1R). The classical view of the system includes the ACE/Ang II/AT1R arm that exerts sodium and water retaining, vaso...
Angiotensin II type 1 receptor (AT1R) is a promising therapeutic target for cardiovascular diseases. Compared with orthosteric ligands, allosteric modulators attract considerable attention for drug development due to their unique advantages of high selec
Wu et al, "Selective Angiotensin II AT2 Receptor Agonists," J. Med. Chem. (2006), Vol 49, pp. 7160-7168. REINECKE, K. et al., "Angiotensin H Accelerates Functional Recovery in the Rat Sciatic Nerve In Vivo: Role of the AT2 Receptor and the Transcription Factor NF-KB1,'' FASEB J...
Evolution of a series of non-quinoline leukotriene D4 receptor antagonist; synthesis and sar of benzothiazoles and thiazoles substituted benzyl alcohols as... Replacement of the quinoline pharmacophore of verlukast by alkylthiazoles and benzothiazoles has lead to the discovery of a new series of ...
Angiotensin II (AngII) type I receptor (AT1R) recognizes AngII, a cardiovascular peptide hormone that acts as a terminal effector of the renin-angiotensin system (RAS). AT1R belongs to the rhodopsin-like peptidergic family of G protein-coupled receptors (GPCRs) and serves as a therapeutic target...