A. Ben-Naim, "Pitfalls in Anfinsen's Thermodynamic Hypothesis," Chemical Physics Letters, Vol. 511, No. 1-3, 2011, pp. 126-128. http://dx.doi.org/10.1016/j.cplett.2011.05.049A. Ben-Naim, “Pitfalls in Anfinsen’s Thermodynamic Hypothesis,” Chemical Physics Letters, Vol. 511, No. ...
进一步的实验确定了变 性的核糖 酶完全恢复其活性的条件,在此基础上,Anfinsen 提出了蛋白质折叠的热力学假说 (thermodynamic hypothesis )。根据此假说,一个蛋白质的天然三维构象对应于在生理条件下其所处 的热力学最稳定的状态。热力学稳定性由组成的氨基酸残基之间的相互作用决定,于是蛋白质的三维 构象直接由它的一...
Cooperative (rather than stepwise or random) release of the chain was suggested, because in this hypothesis all regions of the primary structure are available more or less simultaneously, so that there are no constraints due to unavailability of certain regions on the interactions possible within ...
Hypothesis Chaperone-percolator model: a possible molecular mechanism of Anfinsen-cage–type chaperones Peter Csermely Article first published online: 11 OCT 1999 DOI: 10.1002/(SICI)1521-1878(199911)21:11<959::AID-BIES8>3.0.CO;2-1 Copyright © 1999 John Wiley & Sons, Inc....
While the thermodynamic hypothesis has been dominant since the 1970s, here it is argued that the experimental evidence favours the kinetic hypothesis, particularly in what concerns folding in vivo. A specific kinetic process, designated as the VES KM, is proposed. According to the VES KM the ...
Kresge N, Simoni RD, & Hill RL (2006) The thermodynamic hypothesis of protein folding: The work of Christian Anfinsen. Journal of Biological Chemistry 281:1839-1844.Kresge N, Simoni RD, Hill RL. The thermodynamic hypothesis of protein folding: the work of Christian Anfinsen. J Biol Chem. ...