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The first 72 h following aneurysm rupture play a key role in determining clinical and cognitive outcomes after subarachnoid haemorrhage (SAH). Yet, very little is known about the impact of so called “early brain injury” on patents with clinically good grade SAH (as defined as World Federation...
Kevin N. Sheth Department of Neurosurgery, Yale New Haven Hospital, New Haven, CT, USA Kevin N. Sheth Corresponding author Correspondence toJ. Marc Simard. Ethics declarations Conflict of interests Dr. Simard holds a US patent (7,285,574), a novel non-selective cation channel in neural cells...
7.Sánchez-Peña P, Pereira AR, Sourour NA, Biondi A, Lejean L, Colonne C, et al. S100B as an additional prognostic marker in subarachnoid aneurysmal hemorrhage. Crit Care Med 2008;36:2267–73.10.1097/CCM.0b013e3181809750Search in Google ScholarPubMed ...
Inclusion criteria were: age >18 years, spontaneous aneurysmal SAH diagnosed by computed tomography (CT) within 24 h of ictus, and aneurysm detected on digital subtraction angiography (DSA). Exclusion criteria were: traumatic SAH, pregnancy, hospital admission later than 24 h after ictus, no ...
post-SAH complications, aneurysm treatment, and clinical outcome (modified Rankin scale and Glasgow outcome scale) were retrieved to allow different subgroup analysis.Results:Serum IL-6 levels were significantly raised after aSAH compared to healthy controls over the first two weeks after hemorrhage. Se...
Serum IL-6 was elevated in different aSAH associated complications, acting as a non-specific marker for post-SAH complications and an important biomarker for clinical outcome at discharge. Keywords: aneurysm; subarachnoid hemorrhage; inflammation; interleukin-6 (IL-6); clinical outcome; post-SAH ...