years after the surgery. Cognitive dysfunction dropped to 24% at 6 months only to rise to 42% at 5 years. My sense is that this demonstrates how the body compensates in the short term. However, in the long term, the compensation strategies are exhausted and the cognitive impairment worsens...
Postoperative cognitive dysfunction (POCD),which is more serious and can lead to long-term memory loss and cognitive decline. Patients who suffer from heart and/lung disease,Parkinson’s disease, orAlzheimer’s diseaseor who have hadstrokesin the past are at a higher risk for POCD. The ASA r...
However, neuroadaptation prevents opioids' ability to provide long-term analgesia and produces opposite effects, i.e., enhancement of existent pain and facilitation of chronic pain development. Neuroadaptation to opioids use results in the development of two interrelated phenomena: tolerance and "opioid...
Ketamine/xylazine are used despite the fact that they provide short-term surgical anesthesia (~ 20 min.), while laminectomy is a longer procedure. Therefore, we do not recommend this compound. To make a model of complete-crush transection SCI, mice were anesthetized using isoflurane [155]. ...
and dental damage cause significant patient distress but no long-term morbidity, whereas cardiac, respiratory and renalperioperative complicationsare associated with long-term morbidity and mortality. All complications have associated costs to patients and thehealth system. By appropriately assessing patients...
It’s rare, but you can still be awake after you get general anesthesia. It’s even more unlikely, but you can feel pain during the surgery and not be able to move or tell the doctor you’re awake and in pain. Being awake during surgery can cause long-term emotional problems. ...
Because of the muscle relaxants given before surgery, people are unable to move or speak to let doctors know that they are awake or experiencing pain. For some patients, this may cause long-term psychological problems, similar to post-traumatic...
BACKGROUND: Awareness during anesthesia is a serious complication with potential long-term psychological consequences. Use of the bispectral index (BIS), d... None - 《New England Journal of Medicine》 被引量: 1680发表: 2008年 Regional anesthesia in the anticoagulated patient: defining the risks...
Opioid-free anesthesia opioid side effects: Tolerance and hyperalgesia. Opioids are the most potent drugs used to control severe pain. However, neuroadaptation prevents opioids' ability to provide long-term analgesia and produc... Patricia,Lavand'homme,Arnaud,... - 《Best Practice & Research Clinic...
Recent studies in rodents have shown that inappropriate and high doses of anesthetic agent may result in neuronal apoptosis with the theoretical risk of long-term neurodevelopment problems; this is actually a controversial topic. It has been shown that neuroapoptotic effects are dose-dependent and th...