The on-drug score was then taken 1 hour after a suprathreshold levodopa dose, based on calculation of the levodopa equivalents of the patient’s morning medication. The same doses were used for baseline and follow-up assessment. Stimulators were turned on at the follow-up assessments. In ...
22 Taking this consideration into account, a treatment group difference of 4 points was considered to be clinically relevant in SIESTA, and this difference was used as a basis for sample size calculation. A comprehensive literature search showed a high variability in the standard deviation of the ...
There are more adults living with congenital heart disease than children. Many of these adults with congenital heart disease (ACHD) will require a surgery or intervention, which may or not be related to their congenital heart disease (CHD). The successfu
The invention described herein provides a practitioner two opportunities to adjust the calculation of the amount of the drug delivered to the patient. First, after evaluating the maximum amount of drug that the patient can require and withstand, the practitioner adjusts the concentration of the drug...
the animals were sacrificed by deep general anesthesia. Analgesia was defined as an at least 50% increase in the time required for tail removal, compared to the observed baseline value. Calculation of the maximum possible effect (%MPE) was performed by subtracting the baseline from the latency ...
First, the sample size calculation used an SD of 25 mL, which yielded 98 patients per arm. Second, these 98 patients were mistakenly taken as the entire sample size. Thus, to preserve the protocol with the original sample size of 128 patients, a 30% attrition rate was added in the ...
First, the sample size calculation used an SD of 25 mL, which yielded 98 patients per arm. Second, these 98 patients were mistakenly taken as the entire sample size. Thus, to preserve the protocol with the original sample size of 128 patients, a 30% attrition rate was added in the ...