本发明涉及式(I)化合物及其可药用的溶剂化物以及它们在治疗由雄性激素敏感的和传递的疾病中的应用,其中碳原子1和2以单键或双键相连接;RRR其中X,W,Z,R The present invention relates to formula (I) and their pharmaceutically acceptable solvates and their use in the treatment of androgen-sensitive diseases...
The present invention relates to certain substituted 17 beta -substituted carbonyl-6-azaandrost-4-en-3-ones of formula (I), wherein R<1> and R<2> i) are independently hydrogen or lower alkyl and the bond between the carbons bearing R<1> and R<2> is a single or a double bond, or...
The present invention relates to the compound of formula (I), ##STR1## also known as 17β-N-(2,5-bis(Trifluoromethyl))phenylcarbamoyl-4-aza-5α-andros t-1-en-3-one, solvates thereof, its preparation, in
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A compound of formula (I) wherein carbons 1 and 2 are joined by either a single or a double bond; R<1> is hydrogen or methyl; R<2> is hydrogen or methyl; R<3> is (A) wherein R<4> and R<5> are independently hydrogen, straight or branched alkyl of 1 to 6 carbon atoms,...
Androstenone derivative本发明涉及式(1)的化合物,也称作17β-N-(2,5-双(三氟甲基)苯基氨基甲酰基-4-氮杂-5α-雄-1-烯-1-酮,其溶剂化物,它的制备方法,在其制备中使用的中间体,其药物制剂以及它在雄激素相关和调节的疾病的治疗方面的用途. The present invention relates to compounds of formula (1),...
A compound of formula (I)\nwherein R4 and R5 are independently hydrogen, straight or branched alkyl of 1 to 6 carbon atoms, straight or branched alkoxy of 1 to 6 carbon atoms, trifluoromethyl, cyano, halogen, phenyl (optionally substituted with one or more halogens), or when R4 and R5...
A compound of formula (I) wherein carbons 1 and 2 are joined by either a single or a double bond; R<1> is hydrogen or methyl; R<2> is hydrogen or methyl; R<3> is (A) wherein R<4> and R<5> are independently hydrogen, straight or branched alkyl of 1 to 6 carbon atoms,...
A process of providing novel compounds of Formula (I), that are useful as 6-azaandrostenone testosterone 5-alpha-reductase inhibitors, from commercially available compounds of Formula (II) +TR wherein the substituents are as defined in the specification, and the pharmaceutically acceptable salts ...
(Formula III) wherein: Het represents -O-, -CH2-, -S(O)r-, -NH- or -N(Alk<1>-H)-; optionally substituted with one or more alkyl groups; R<5> and R<6> represent H or alkyl; R<7> represents hydroxy, alkoxy, halogen or OCOR<14>, wherein R<14> represents H, alkyl, aryl...