The principle of the following enzyme immunoassay test follows the typical competitive binding scenario. Competition occurs between an unlabeled antigen (present in standards, controls and human samples) and an enzyme-labelled antigen (conjugate) for a limited number of antibody binding sites on the ...
Trans-3'-hydroxycotinine is a major metabolite of nicotine in humans and is mainly excreted as O-glucuronide in smoker's urine. Incubation of human liver microsomes with UDP-glucuronic acid produces not only trans-3'-hydroxycotinine O-gl... Yamanaka,H Nakajima,M Katoh,... - 《Drug Metaboli...
Identification, Ki determination and CoMFA analysis of nuclear receptor ligands as competitive inhibitors of OATP1B1-mediated estradiol-17β-glucuronide tr... Evidence shows that drug–drug interactions can occur at the level of drug transporters such as the organic anion transporting polypeptides (OAT...