Androgen excess in women typically presents clinically with hirsutism, acne or androgenic alopecia. In the vast majority of cases, the underlying aetiology is polycystic ovary syndrome (PCOS), a common chronic condition that affects up to 10% of all women. Identification of women with non-PCOS ...
Androgen levels, like progesterone and estrogen levels, may fluctuate during themenstrual cycle. In studies of women with regular menstrual cycles, the average total testosterone among all participants peaked mid-cycle (13,14), with some studies showing a peak around the time of the luteinizing hor...
In April 2011, the International Olympic Committee (IOC) and the International Association of Athletics Federations (IAAF) updated their regulations regarding elite female athletes with hyperandrogenism: Women whose testosterone levels crossed into the male range could not compete with other women unless...
greater risk of amenorrhea development in young women with irregular cycles with an average length of 33 to 41 days versus 22 to 34 days. Flug and colleagues46reported that 92% of girls with cycles of 21 to 34 days had normal adult cycles in contrast to 66% with cycles of 35 to 40 da...
Although osteoporosis (brittle bone disease) is usually thought of as occurring mainly in women, the disease in men is commonly caused by low testosterone. Low testosterone levels can cause bones to thin, weaken, and become more likely to fracture. ...
In recent decades, the prevalence of type 2 diabetes (T2D) has rapidly increased worldwide, becoming a global health issue1. Of note, population studies have reported a higher prevalence of T2D in men than in women2,3. Consistent with humans, male mice have lower insulin sensitivity than fem...
In normal adults about 55% of T in men or E2 in women is bound to circulating SHBG. The remainder is loosely bound to bulk carrier proteins like albumin and only 1–3% of sex steroids normally circulate freely5. In clinical practice, free sex steroid concentrations are calculated from total...
Prostate cancer incidence increases with age and has been reported in HIV-infected men, but data on the results of PSA testing in older HIV seropositive men are limited.Standardized interviews on demographics, behaviors, and medical hist... R Klein - 《Idsa》 被引量: 0发表: 2005年 Androgen...
Central obesity and insulin resistance (IR) are common conditions in women with polycystic ovary syndrome (PCOS) and in subjects with non-alcoholic fatty liver disease (NAFLD). However, few studies have addressed the association between hyperandrogenism (HA) and NAFLD. We aimed to determine whethe...
LIMITATIONS REASONS FOR CAUTION: Variability was present in the metabolic parameters measured; however, this is similar to the heterogeneity observed in human populations. WIDER IMPLICATIONS OF THE FINDINGS: Chronic hyperandrogenemia beginning at puberty may exacerbate metabolic dysfunction in women ...