Studies the side-effects of using androgen therapy in the treatment of prostate cancer by researchers from Boston, Massachusetts. Credibility to propositions that the adverse side effects of hormone the...
Androgen suppression therapy represents an alternative to invasive approaches for the management of symptomatic benign prostatic hyperplasia. Androgen withdrawal from the prostate has been associated with the activation of specific genes involved with programmed cell death, or apoptosis. Luteinizing hormone-...
The rationale behind intermittent androgen suppression (IAS) is based on: (1) observations that androgen ablation is palliative, not curative in most patients where quality of life must be considered; (2) assumption that immediate androgen ablation is superior to delayed therapy in improving survival...
Economic analysis of a phase III clinical trial evaluating the addition of total androgen suppression to radiation versus radiation alone for locally advan... Purpose: To evaluate the cost-effectiveness of adding hormone therapy to radiation for patients with locally advanced prostate cancer, using a ...
Standard medical castration reduces muscle mass. We sought to characterize body composition changes in men undergoing maximal androgen suppression with and without exogenous gluocorticoids. Cross-sectional areas of total fat, visceral fat and muscle were
Influence of androgen suppression therapy for prostate cancer on the frequency and timing of fatal myocardial infarctions. J Clin Oncol. 2007;25(17):2420-2425. Alibhai SM, Duong-Hua M, Sutradhar R, et al. Impact of androgen deprivation therapy on cardiovascular disease and diabetes. J Clin ...
Androgen Deprivation Therapy and the Re-emergence of Parenteral Estrogen in Prostate Cancer Androgen deprivation therapy (ADT) resulting in testosterone suppression is central to the management of prostate cancer (PC). As PC incidence increases, A... I Phillips,SIA Shah,T Duong,... - 《Oncol He...
D’Amico AV, Manola J, Loffredo M, Renshaw AA, DellaCroce A, Kantoff PW. 6-month androgen suppression plus radiation therapy vs radiation therapy alone for patients with clinically localized prostate cancer: a randomized controlled trial.JAMA. 2004;292(7):821-827. doi:10.1001/jama.292.7.821...
External Beam Radiation Therapy and Abiraterone in Men With Localized Prostate Cancer: Safety and Effect on Tissue Androgens Optimizing androgen suppression may provide better control of localized prostate cancer (PCa). Numerous trials have supported the benefit of combining andr... Eunpi Cho MD,Elahe...
In human hepatocellular carcinoma cells, AhR-dependent effects of flutamide were mediated by the induction of transforming growth factor-β1 (TGF-β1) [55] (Fig. 2B). As a pharmaceutical, flutamide is used in a therapy of advanced androgen-dependent prostate cancer. The recommended dosage is ...