Itching, or pruritus, is defined as an unpleasant cutaneous sensation that serves as a physiological self-protective mechanism to prevent the body from bei... YG Sun,ZF Chen - 《Nature》 被引量: 893发表: 2007年 Sexual differentiation of the vertebrate nervous system Understanding the mechanisms ...
Ketoconazole is used as an inhibitor of adrenal androgen synthesis in men with androgen-independent prostate cancer. This study analyzes the relationship between pretreatment androgen levels and outcome following ketoconazole treatment. EXPERIMENTAL DESIGN: Baseline levels of three adrenal androgens (...
As indicated in the recent Adolescent Consensus Statement,20 hyperandrogenemia needs to be defined based on the characteristics of the testosterone assay that is used, and biochemical evidence of hyperandrogenism, at this time, seems to provide the best support for the presence of hyperandrogenism...
is composed of three major functional domains: amino-terminal (transcription-regulating), DNA-binding (zinc finger), and steroid-binding. This protein plays a key role in mediating androgenic effects on external genital development during normal male sex differentiation, as evidenced by mutations in ...
carrier is defined as an individual who tests positive for the hepatitis B surface antigen (HBsAg). Written informed consent was obtained from all study par- ticipants, and the investigation was approved by the research ethics committee at the College of Public ...
The androgen receptor (AR) pathway is emerging as a potential therapeutic target in breast cancer. To date, AR-targeted drugs have been approved only for treatment of prostate cancer; however, AR-targeted treatment for breast cancer is an area of active investigation. Through review of preclinical...
(PSA) progression after first-line combined hormonal therapy were enrolled.43cases of them were administrated with bicalutamide (50mg daily), while other 13 cases were administrated with flutamide (250mg tid), the response of the second-line therapy was defined as a decrease of 50% from the ...
As defined, the hyperinsulinemic patients had higher basal and peak insulin levels and areas under the insulin response curve compared with the normoinsulinemic patients or controls. Total testosterone and dehydroepiandrosterone did not differ among study groups. As expected, hyperandrogenic patients ...
Reijke s classification.The four groups w ere defined as the following:(1) Gl g:surgical castration with a good progno。 sis score,(2) Gl p:surgical castration with a poor prognosis Acta P ha rma co lo gica S inica score,(3) G2g:medical castration with a good prognosis score...
information is available conceming the specific re- gional regulation of aromatase mRNA expression. We have previously reported an in situ hybridization (ISH) protocol allowing the detection of aromatase mRNA in specific regions of the rat brain as early as ...