A representative example of the phenotype for a trained and untrained human paralyzed muscle.Michael A. PetrieManish SunejaElizabeth FaidleyRichard K. Shields
C1-FFL is capable of filtering noise asymmetrically to have a precise and robust phenotype of a particular trait (or cellular function) [9]. I1-FFL, as a noise-buffering motif, can facilitate adaptive tuning of gene expression through modulation of TF binding affinities [10]. FFLs are ...
MV released from cells activated by inflammatory and thrombotic factors have the potential to disrupt endothelial cells of the brain microvasculature. Therefore, experiments were designed to identify sex differences in the phenotype of MV released from cultured human brain microvascular endothelial cells (...
Damage in the ischemic core and penumbra after stroke affects patient prognosis. Microglia immediately respond to ischemic insult and initiate immune inflammation, playing an important role in the cellular injury after stroke. However, the microglial het
“With AI, we can develop more accurate disease and phenotype prediction models through the in-depth analysis of desensitized gene data.” This, she says, will help us build a more detailed genetic structure of the population and hopefully find new drug targets. For example, non-invasive ...
A challenge also arises when studying the sex-specific effects of mutations that have a universally harmful postnatal phenotype, for example when assessing the reproductive consequences of mutations affecting cell division or DNA repair. In these instances, the unrequired sex also suffers the ill-effect...
4.3.1 Define genotype, phenotype, dominant allele, recessive allele, co-dominant alleles, locus, homozygous, heterozygous, carrier and test cross. Genotype: the alleles of an organism. Phenotype: the characteristics of an organism. Dominant allele: an allele that has the same effect on the phenot...
In situ sequencing and capture techniques have been applied to the mechanistic study and therapeutic target discovery of tuberculosis [125,126,127] and influenza infections [128]. For example, a study used mice infected with H1N1 as the model for studying ARDS [129], demonstrating that over-acti...
Phenotype The observable characteristics of an organism, which results from the genotype and its interaction with the environment. Non-coding RNAs RNAs transcribed from the genome that do not serve as templates for proteins (for example, microRNAs). Ubiquitin–proteasome system An ancient system conser...
An example of such behavior is shown in the left panel of Figure 4. Figure 4. Numerical simulations of system (1)–(6). Behavior of solution for different initial viral loads in the bistable case. Left two columns: initial viral load 𝑉(0)=141·103V(0)=141·103 leads to the ...