From the cross-ancestry meta-PheWAS analysis, six traits exhibited evidence of heterogeneity (defined as when thep-value of the Cochran’s heterogeneity test is below Bonferroni threshold) as shown in Table3, Supplementary Figs.1–7. For example, incardiac dysrhythmias (427)the signal indicated s...
We assembled an ancestrally diverse collection of genome-wide association studies (GWAS) of type 2 diabetes (T2D) in 180,834 affected individuals and 1,159,055 controls (48.9% non-European descent) through the Diabetes Meta-Analysis of Trans-Ethnic association studies (DIAMANTE) Consortium. Multi...
BGA prediction accuracy was assessed using samples from individuals who self-declared their ancestry as being from single populations of origin (n = 36) or from multiple populations of origin (n = 14). Sequencing was conducted on Ion 318™ chips (TFS) on the Ion PGM™ System (TFS). ...
In parallel with this initiative of improving LAI analysis accuracy, our working group is developing a friendly pipeline for Tractor so other consortia can apply this approach for large sample sizes. As a future perspective, the PGC-PTSD ancestry working group will also work on the development of...
interrogation was performed under approval granted by the St. Vincent’s Sydney HREC (#SVH/15/227) and an executed material and data sharing agreement between the University of Pretoria in South Africa and University of Sydney in Australia. While data is shared, all data remains the property ...
. We then randomly selected 466 genes from 18,383 protein-coding genes using by the PoPS as the reference group to estimate the number of lipid-related publications we would expect to see by chance. A Mann–WhitneyUtest showed that there was a significant difference (W = 52,353,p-...
Meta-analysis Initiative (GBMI) is a collaborative group that currently involves 19 biobanks from 12 countries spanning 4 different continents: North America (Canada, USA), East Asia (China, Japan), Europe (Iceland, Estonia, Finland, the Netherlands, Norway, Scotland, UK), and Australia. Each...
In my case, I took the original Ancestry test and, later, the V2 test, which is why you see my name twice on the list, above, of DNA tests that I have access to. Updated Regions Ancestry has updated the regions and subregions that they report in their ethnicity, now “Ancestral ...
Recently, Ancestry introduced a new view of your ethnicity called SideView™. In a nutshell, AncestryDNA uses your DNA matches to attempt to divide your ethnicity into regions inherited from Parent 1 and Parent 2. Based on your matches and the common D
For the protein quantitative trait loci (pQTLs) from blood, we either did not find the genes in the cohort or the number of SNPs within the gene was too low (<20) to test for colocalization (Supplementary Table 3). No variants were associated at genome-wide significance in the GWAS in...