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We performed three genome-wide meta-analyses (cross-ancestry, European, and East Asian) for SU using GWAS summary statistics from the Chronic Kidney Disease Genetics Consortium (CKDGen,N = 457,690)13, UK Biobank (UKBB,NEUR = 388,724,Nnon-EUR = 72,170)15, Biobank Japan (BB...
adjusting for age, sex, height, cigarette smoking, weight (for FVC only), and center, ancestral principal components, and a random familial effect to account for family relatedness when appropriate. Ancestry-specific fixed-effects inverse-variance weighted meta-analyses of study-specific results, with...
Following cleavage and release from the membrane, JPH2 can translocate to the nucleus, bind DNA, and repress genes implicated in cell growth and differentiation, hypertrophy, inflammation, and fibrosis in cardiomyocytes [77]. The sodium voltage-gated channel alpha subunit 3 gene (SCN3A) encodes ...