It is still unclear whether primary adjuvant treatment extended beyond 5 years is of benefit and whether primary adjuvant treatment with anastrozole for 5 years is preferable to switching to anastrozole after 2-3 years of tamoxifen treatment. However, the evidence to date establishes anastrozole as ...
Backround: 5 yrs of adjuvant tamoxifen (Tam) substantially reduces recurrence and mortality in ER+ breast cancer. Two to five years of late extended AI (anastrozole, exemestane or letrozole) adjuvant therapy after 鈭 5 years of Tam has b... P Goss,E Mamounas,R Jakesz,... - 《Cancer ...
Neoadjuvant Treatment of Postmenopausal Breast Cancer With Anastrozole, Tamoxifen, or Both in Combination: The Immediate Preoperativ... Switching of postmenopausal women with endocrine-responsive early breast cancer to anastrozole after 2 years' adjuvant tamoxifen: co......
The cumulative incidences of all first fractures (both serious and non-serious, occurring either during or after treatment) was higher in the ARIMIDEX group (15%) compared to the tamoxifen group (11%). This increased first fracture rate during treatment did not continue in the post-treatment f...
The anastrozole group had fewer adverse events leading to stopping therapy and a modestly higher score in global indices of quality of life.Despite these findings, the timing of aromatase inhibitor therapy remains controversial: Should it be used initially or only after 2 to 3 years of tamoxifen ...
In total, 50 patients had evaluable data.Results: Following anastrozole treatment, the lumbar spine median BMD increased by 2.35% (P = 0.04) and 4.02% (P = 0.0004) at years 6 and 7, while total hip median BMD increased by 0.71% (P = 0.3) and 0.5% (P = 0.8). After tamoxifen ...
of reproductive potential of the potential risk to a fetus. Advise females of reproductive potential to use effective contraception during therapy with anastrozole and for at least 3 weeks after the last dose[see Use in Specific Populations (8.1,8.3) and Clinical Pharmacology (12.1)...
of anastrozole, estradiol levels are reduced to undetectable levels, with no adverse effects on levels of any other horm one, including cortisol and aldosterone. Maximal estrogen suppression is produced by a 1mg dose. Estrogen suppression is maintained for up to 6 days after discontinuing anastrozole...
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Clinical trial data have shown that among breast cancer patients who were disease free after 5 years of adjuvant treatment with tamoxifen, further extended treatment with the nonsteroidal aromatase inhibitor letrozole reduces breast cancer recurrence. We examined the efficacy and tolerability of extended ...