La thymidine kinase des virus est moins spécifique que la thymidine kinase des cellules humaines et permettent donc de phosphoryler des analogues de bases. fr.wikipedia.org Les chiffres ternaires sont connus sous le nom de trit (trinary digit), de manière analogue à bit. ...
Parasites were grown in RPMI-1640 media (Sigma- Aldrich, SKU R4130) supplemented with 27 mM sodium bicarbonate, 11 mM glucose, 5 mM HEPES, 1 mM sodium pyruvate, 0.37 mM hypoxanthine, 0.01 mM thymidine, 10 μg ml−1 gentamycin (Sigma-Aldrich) and 0.5% Aw5%...
Their incorporation into growing DNA results in chain termination; selectivity is determined by the viral thymidine kinase, required for the efficient conversion into the mono and subsequent triphosphorylated derivatives needed for incorporation into DNA62. However they have also been shown to reduce HIV...
Cezar-de-Mello P F T,Vieira A M,Nascimento-Silva V,Villela C G,Barja-Fidalgo C,Fierro I M.ATL-1, an analogue of aspirin-triggered lipoxin A4, is a potent inhibitor of several steps in angiogenesis induced by vascular endothelial growth factor.British Journal of Pharmacology. 2008...