RA is an autoimmune disease, meaning the immune system attacks its own body. In this systemic disorder, immune cells attack and inflame the membrane around joints. Is an ANA of 160 high? A titer of 1:160 or above is commonly considered a positive test result. Other conditions with ANA ...
The “gold standard” serologic test for diagnosis of HGA in humans is an indirect immunofluorescence assay (IFA). This assay must be performed at multiple time points over a period of several weeks and can only be performed in specialized reference laboratories. A limitation of the IFA assay ...
If the value of the F test shows that the data are significant, than it is concluded that there is a “gene” effect, meaning that not only presence or the position of the gene is causing the effect. The threshold for significance for a true global gene effect is set at 5% probability...
Immunodominant epitope: The epitope on a molecule that induces a dominant, or most intense, immune response. The immunodominant epitope may elicit, for example, the greatest antibody titer during infection or immunization, as measured by, for example, the fraction of reactivity attributable to a cer...
The existence of different techniques that allow us to evaluate the presence of the same parameter, ANAs in this case, should not be used as a limitation but as an advantage, since a test result with a high sensitivity, such as when using a HEp-2 IIF with a 1:80 cut-off titer, is...