Use of Computer-Aided Immunofluorescence Microscopy (CAIFM) for Interpretation of Antinuclear Antibody (ANA) Pattern and Titerantinuclear antibodyautoimmune diseasedigital pathologycomputer-aided immunofluorescence microscopyThe assessment of antinuclear antibodies (ANA) by indirect immunofluorescence (IFA) allows ...
When interpreting ANA test results, doctors typically look at the titer level and the staining pattern under a microscope. A higher titer, such as 1:160 or above, may indicate a greater likelihood of an autoimmune condition, while lower titers, like 1:40, can be found in healthy individuals...
RA is an autoimmune disease, meaning the immune system attacks its own body. In this systemic disorder, immune cells attack and inflame the membrane around joints. Is an ANA of 160 high? A titer of 1:160 or above is commonly considered a positive test result. Other conditions with ANA ...
Using the ANA-IIF test on HEp-2 cells results in the detection of high-titer antibodies with a DFS70-like pattern in 1% to 15% of cases in patients referred for ANA testing (Dellavance et al., 2005, Bizzaro et al., 2007, Kang and Lee, 2009, Mahler et al., 2012a, Miyara et al...
Taking all of this into account, an important consideration regarding ANAs is the fact that whenever a positive result is obtained, both the IIF pattern and the titer must be reported, including nuclear, cytoplasmic, and mitotic patterns. As is known, estimates of the title-specific likelihood ...