The presence of ANA with a homogeneous & speckled (HS) pattern was significantly associated with the absence of cancer (p < 0.01). Patients with a HS pattern were found to have a lower relative risk (RR 0.7, 95%CI 0.5-0.9) of having cancer compared to those with other patterns. Can ...
For example, the nucleolar pattern is more commonly seen in the disease scleroderma, while the homogeneous pattern is often associated with systemic lupus erythematosus (SLE). The ANA speckled pattern, on the other hand, is seen in many conditions including Sjögren's syndrome and mixed ...
Homogeneous:Total nuclear fluorescence due to an antibody directed against DNA or histone proteins. Common insystemic lupus erythematosus. Peripheral:Fluorescence occurs at the edges of the nucleus in a shaggy appearance. Anti-DNA and anti-nuclear envelope antibodies cause this pattern. Seen in systemic...