we use a genome-wide interference screen to determine invasion-essential genes and identify the AN1/A20 zinc finger domain containing protein 3 (ZFAND3) as a crucial driver of GBM invasion. Using patient-derived cellular models, we show that loss of ZFAND3 hampers the invasive capacity of GB...
to type I receptors is accelerated [217,218]. There are clear domains on BMP-2, −4, and −7 ligands that bind specifically to the type I receptors [221]. Afterligand binding, type II receptor kinase activity transphosphorylates the type I receptor through an SGSGS motif (GS domain)...
Finally, the complete structural model of FPR1 was obtained by comparative modeling, using as templates the obtained models for N-terminal and trans-membrane regions and for C-terminal domain. The final structure had 96.8% of the residues in allowed regions in the Ramachandran Plot, and an ...
From OA genetics, a four-gene (C–C Motif Chemokine Receptor 6 (CCR6), C-Type Lectin Domain Containing 7A (CLEC7A), Interleukin 18 (IL18) and Serine And Arginine Rich Splicing Factor 2 (SRSF2))45 and another seven-gene46 (Collagen Type VI Alpha 3 Chain (COL6A3), Collagen Type I ...
PURPOSE: A recombinant combo protein fused with HIV type-1, -2 and 0 proteins, a manufacturing method thereof, a vector containing the same and a transformant thereof, a diagnostic kit thereof and a composition for vaccine thereof are provided. The recombinant combo protein has improved HIV ...
All retroviruses contain, in the nucleocapsid domain of the Gag protein, one or two copies of the sequence Cys-X2-Cys-X4-His-X4-Cys. We have generated a se... RJ Gorelick,SMN Jr,JWB Jr,... - 《Journal of Virology》 被引量: 642发表: 1990年 Determination of the structure of the ...
The purified protein had aggrecanase activity and appears as two major bands on the silver stained SDS-PAGE corresponding well to a pro-domain on form of 115 kDa and a pro-domain off form of 90 kDa. Using denatured type I collagen in zymographic analysis we demonstrate that ADAMTS-1 has ...
NEURALREGENERATlONRESEARCH Volume6,Issue7,March2011 Ⅵ,V州 .nrronline.org Citethisarticleas:NeuralRegenRes.2011;6(7):542-545 Constructionandexpressionofanoptimized,novel humanimmunodeficiencyvirustype一1lentiviral vectorcontaininggreenfluorescentprotein★★ XiaLi’,2XuelingMa。 ,LijingZhao’,HangGao4,Hong...
Article: Site-specific phosphorylation of the human immunodeficiency virus type-1 Rev protein accelerates formation of an efficient RNA-binding con
S-mTFD-MPPB-binding sites at subunit interfaces within the transmembrane domain of an α1β3γ2 GABAAR. A–F, views are shown of an α1β3γ2 GABAAR homology model built using the β3 GABAAR crystal structure (PDB 4COF), with subunits color-coded (α1, light yellow;β3, light blue...