This issue contains a mini-symposium entitled 'New perspectives on iron in clinical medicine', which aims to provide an update on some areas in which our knowledge has grown considerably in the last few decades. Iron in clinical medicine represents a broad topic-few nutrients have been so ...
On this page Chapters and Articles Related Terms Recommended Publications Featured Authors Chapters and Articles You might find these chapters and articles relevant to this topic. Brain Imaging Update Chester A.MathisPhD, ...William E.KlunkMD, PhD, inSeminars in Nuclear Medicine, 2012 ...
focus on extensive investigation of parasite-host interactions, identification and exploitation of several checkpoint targets in parasite pathogenesis, as well as an in-depth understanding of the biochemical differences between host and parasite structure and physiology at the molecular and cellular levels....
an event that leads to cleavage of pro-IL-1β and pro-IL-18 into their mature forms and cleavage of GSDMs, inducing pore formation in the plasma membrane and release of cytokines. Ferroptosis is a regulated cell death programme dependent on iron and resulting in lipid peroxidation of the ph...
aIron, one of the most abundant metals on Earth, is essential to most life forms and to normal human physiology. Iron is an integral part of many proteins and enzymes that maintain good health. In humans, iron is an essential component of proteins involved in oxygen transport [1,2]. It ...
In iron–sulphur clusters two, three or four atoms of iron are attached to the protein through two or four sulphydryl groups. Uncoupling proteins Proteins in the mitochondrial inner membrane that can divert the proton gradient away from the formation of ATP, resulting in the generation of heat...
These events may be important for both physiology and pathology. Alpha cleavage prevents the C1 fragment from being converted into PrPSc [21], the rate of the beta cleavage is increased in the disease [19], and PrPC deletion mutants lacking the alpha-cleavage site show spontaneous ...
[13,14]. A gastric Bypass involves restricting the volume of food which can be eaten by creating a small thumb-sized pouch from the upper stomach and a bypass of the remaining stomach. Bypass alters physiology and anatomy in such a way as to achieve early and generally rapid weight loss ...
Cell Biology and Physiology of the Intestinal Epithelium Theintestinal epitheliumconsists of 2 regions known as the crypt, at the base, and the villus, at the tip. The crypt-villus axis provides the architecture necessary for continuous proliferation and replacement of dying and damaged mature cells...
This review provides a comprehensive analysis of the mitochondrial pathway of cell death and of its multifaceted implications for human physiology and pathology. CAS PubMed Google Scholar Green, D. R. & Kroemer, G. Pharmacological manipulation of cell death: clinical applications in sight? J. ...