Aggarwal S, Thareja S, Verma A, Bhardwaj TR, Kumar M. An overview on 5alpha‑reductase inhibitors. Steroids 2010;75:109‑53.Aggarwal S, Thareja S, Verma A, Bhardwaj TR, Kumar M. An overview on 5alpha-reductase inhibitors. Steroids. 2010;75:109–53....
In some respects, effects ofin uteroand lactational TCDD exposure resemble those ofin uteroexposure to the 5α-reductase inhibitors. However, as with antiandrogen exposure,in uteroexposure of male rats to finasteride results infeminizationof external genitalia, hypospadias with cleft prepuce, and nippl...
Two isozymes of 5α-reductase, typ... S Petrini,F Zaccanti - 《Journal of Experimental Zoology》 被引量: 61发表: 1998年 Effects of 5 alpha-reductase inhibitors on intraprostatic androgens in the rat. FCE 27837 is a novel inhibitor of 5 alpha-reductase, the enzyme responsible for the ...
eteplirsen and nusinersen. Occupancy-only ASOs can also activate endogenous cellular surveillance programs that remove abnormal mRNAs. The targets can be degraded via nonsense-mediated mRNA decay (NMD) when ASOs act on pre-mRNAs to create mRNAs with premature termination...
At the doses of methotrexate required for efficacy in cancer, it acts as a competitive inhibitor of dihydrofolate reductase (DHFR), hence it will reduce downstream intermediates of the folate pathway, and ultimately inhibit nucleotide synthesis, resulting in impaired DNA replication and repair.65,66...
In addition, mPTP inhibitors, such as cyclosporine A, were found to reduce infarct size in pre-clinical models of I/R and in humans [160]. Exenatide, an analogue of glucagon-like peptide-1 (GLP-1), was reported to reduce myocardial infarct size and to improve myocardial salvage in ...
Several studies have shown that some plant extracts, such as isoflavones, exert a direct effect on the PSA level and prostate volume, both in patients with prostate cancer and with benign prostatic enlargement. This is due to the direct inhibition of 5-alpha-reductase by isoflavones. Engelhardt ...
(HMG-CoA) reductase inhibitors, for treating hepatitis virus infections has shown encouraging results [109]. Nonalcoholic steatohepatitis (NASH) has been linked to lipid metabolic dysregulation and inflammation in the liver, but the mechanisms behind these associations are poorly understood. NASH is ...
3. Impact of ageing on innate immunity and its restoration Innate immunity is a key element of the immune response including several cellular components such as macrophages, NK cells, and neutrophils, which provide rapid first-line defence against pathogens. The function of these cells declines with...
Bender A, Mussa HY, Glen RC: Screening for Dihydrofolate Reductase Inhibitors Using MOLPRINT 2D, a Fast Fragment-Based Method Employing the Naive Bayesian Classifier: Limitations of the Descriptor and the Importance of Balanced Chemistry in Training and Test Sets. J Biomol Screen. 2005, 10 (7)...