An overview on 5alfa-reductase inhibitorsAggarwal, SaurabhThareja, SureshVerma, AbhilashaBhardwaj, Tilak RajKumar, Manoj
48 Several inhibitors of specific catalytic subunits were developed, such as the β5-specific inhibitor oprozomib (ONX 0912). In addition, several immunoproteasome-specific inhibitors have recently been developed, which represents another milestone in proteasome inhibitor discovery (Fig 2): ONX 0914 ...
Two isozymes of 5α-reductase, typ... S Petrini,F Zaccanti - 《Journal of Experimental Zoology》 被引量: 61发表: 1998年 Effects of 5 alpha-reductase inhibitors on intraprostatic androgens in the rat. FCE 27837 is a novel inhibitor of 5 alpha-reductase, the enzyme responsible for the ...
It is being investigated in clinical trials for the treatment of advanced solid tumors, and its clinical development is focused on combinations with inhibitors of the programmed cell death protein PD-1, a protein on the surface of cells that downregulates the immune system. In order to reduce ...
The growing understanding of RNA functions and their crucial roles in diseases promotes the application of various RNAs to selectively function on hitherto “undruggable” proteins, transcripts and genes, thus potentially broadening the therapeutic targe
Wambua S, Mwangi TW, Kortok M, Uyoga SM, Macharia AW, Mwacharo JK, Weatherall DJ, Snow RW, Marsh K, Williams TN (2006) The effect of alpha + -thalassaemia on the incidence of malaria and other diseases in children living on the coast of Kenya. PLoS Med 3:e158 Willcox M, Bjorkman...
Bidens pilosa L. is an edible herb and has been traditionally used for a wide range of ailments in many countries. The aim of this review is to present com
At the doses of methotrexate required for efficacy in cancer, it acts as a competitive inhibitor of dihydrofolate reductase (DHFR), hence it will reduce downstream intermediates of the folate pathway, and ultimately inhibit nucleotide synthesis, resulting in impaired DNA replication and repair.65,66...
For instance, despite indirect evidence from epidemiologic studies to support the possibility that blockage of the conversion of testosterone to DHT by 5-alpha reductase inhibitors may be associated with increased fracture risk, clinical trial data do not support this. Therefore, this chapter focuses ...
In some respects, effects ofin uteroand lactational TCDD exposure resemble those ofin uteroexposure to the 5α-reductase inhibitors. However, as with antiandrogen exposure,in uteroexposure of male rats to finasteride results infeminizationof external genitalia, hypospadias with cleft prepuce, and nippl...