PURPOSE:To provide the subject inhibitor having an excellent 5alpha-reductase- inhibiting activity and high safety and effective for the therapy of prostatic hypertroply, etc., caused by the action of androgenic hormone by containing an inflavone compound as an active ingredient. CONSTITUTION:A 5...
In the attempt to further investigate the effect of 5AR inhibitors on dyskinesia and shed light on the mechanism of action, in the present study we compared the effect of FIN and dutasteride (DUTA), a potent dual 5AR inhibitor, on the development of LID, on the therapeutic efficacy of L-...
A 5 alpha -reductase inhibitor comprising as an effective component an extract from leaves and/or pericarps of a walnut. The inhibitor exhibits high potent 5 alpha -reductase inhibiting activity and high safety, and is thus effective in curing and preventing diseases caused by testosterone, e.g...
Finasteride a steroid 5-alphareductase inhibitor does not affect the oxidative metabolism of antipyrine. J Clin Pharmacol 1993;33:967-70.Winchell GA, Gregoire S, Taylor AM, Hegland J and Hunninghake DB (1993) Finasteride, a steroid 5␣-reductase inhibitor, does not affect the oxidative ...
Names: Formononetin, Testosterone 5alpha-reductase inhibitorCAS号: 485-72-3 MDL Number: MFCD00016948 MF(分子式): C16H12O4 MW(分子量): 268.26EINECS:207-623-9 Reaxys Number: Pubchem ID: Brand:BIOFOUNT 刺芒柄花素(485-72-3,Formononetin)是大豆食品中发现的一种异黄酮类植物雌激素化合物,...
Dutasteride可抑制C57BL/6 TRAMP x FVB小鼠中5αR1/5αR2,有效阻断前列腺癌的发生和发展。[2] 参考文献 [1] Schmidt LJ1, et al. Gene expression in prostate cancer cells treated with the dual 5 alpha-reductase inhibitor dutasteride. J Androl. 2004 Nov-Dec;25(6):944-53. ...
External genitalia abnormalities in male rats exposed in utero to finasteride, a 5 alpha-reductase inhibitor A series of studies was conducted to determine the developmental toxicity of the 5伪-reductase inhibitor finasteride (MK-0906) in rats. This compound was a... RL Clark,JM Antonello,SJ Gr...
Effects of the dual 5 alpha-reductase inhibitor dutasteride on apoptosis in primary cultures of prostate cancer epithelial cells and cell lines. Watson RW: Effects of the dual 5 alpha-reductase inhibitor dutasteride on apoptosis in primary cultures of prostate cancer epithelial cells and cell lines....
Does 5-alpha reductase inhibitor intake impact procedural efficacy, short- and long-term functional outcomes in patients undergoing Holmium Laser Enucleation of the Prostate (HoLEP)? A retrospective single-center analysis among 1,360 patientsGild P....
Novel substituted benzoyl benzoic acids and phenylacetic acids 1−14 have been synthesized and evaluated for inhibition of rat and human steroid 5α-reductase isozymes 1 and 2. The compounds turned out to be potent and selective human type 2 enzyme inhibitors, exhibiting IC50 values in the nanom...