drug repurposinghigh throughputnatural sourcessmall moleculeA new medicine will take an average of 10-15 years and more than US$2 billion before it can reach the pharmacy shelf. Traditionally, drug discovery relied on natural products as the main source of new drug entities, but was later ...
Drug discoverycan be described as the process of identifying chemical entities that have the potential to become therapeutic agents. A key goal ofdrug discoverycampaigns is the recognition of new molecular entities that may be of value in the treatment of diseases that qualify as presenting unmet m...
Accordingly, the identification of a drug target is the first and foremost step in the drug discovery and development process. Generally, the targets are classified into two categories: one is established/reported drug targets and the other is novel drug targets that are yet to be identified. ...
Here, we provide an overview of how this collaborative effort has enabled the structural determination and characterization of eight human GPCRs so far, ... Stevens,Raymond,C.,... - 《Nature Reviews Drug Discovery》 被引量: 212发表: 2013年 The GPCR Network: a large-scale collaboration to ...
The retroviral vector contained a full-length long terminal repeat (LTR) and CMV promoter, both of which are strong enhancers and are against the present safety criteria. However, the therapy An overview of development in gene therapeutics in China turned out to be safe at least for the first...
Fig. 1: An overview of major developments in the RNA-targeting field. A timeline of RNA-based technological advances, drug approvals and other important events are highlighted. Rapid development in the RNA-targeting field has been applied to treat rare and common diseases. ASOs antisense oligonucl...
This article presents the history of rivaroxaban's development, from the structure–activity relationship studies that led to its discovery to the preclinical and clinical studies, and also provides a brief overview of other oral anticoagulants in advanced clinical development. This is a preview of ...
an overview of the current state of knowledge about oxadiazole-related drugs,emphasizing their biological importance.Key aspects related to the discovery and ... D Kumar,V Kumar,A Deep,... - 衰老通讯 被引量: 0发表: 2023年 Modeling of Dipeptide Sulfonamides as Anti-PlasmodialDrugs: Synthesis, ...
Overview of Drug Development Colin G. Rousseaux, ... Silvia Guionaud, in Haschek and Rousseaux' s Handbook of Toxicologic Pathology, 2023 United States and Canada As of today, the United States is still the most economically important area for new drug filings, with the highest number of new...
Terry P.Kenakin, inPharmacology in Drug Discovery and Development (Second Edition), 2017 Introduction Conventional concepts aboutdrug discoverycenter on the assumption that a drug must have an affinity for a naturally physiologically relevant site on a biological target.For instance, antimuscarinic antag...