首先,研究者检测了NCOR1(编码NCoR)和Ncor2(编码SMRT)在小鼠胚胎成纤维细胞(MEF)、胚胎干细胞(ESC)和OSKM重编程细胞中的表达。结果显示,这两种共抑制因子在三种细胞类型中都有表达。接下来,研究者敲除了用OSKM逆转录病毒转导的OG2 MEF中的NCOR1/2,结果显示敲除任何一个共抑制子都能显著增加Oct4绿色荧光蛋白阳性(...
首先,研究者检测了NCOR1(编码NCoR)和Ncor2(编码SMRT)在小鼠胚胎成纤维细胞(MEF)、胚胎干细胞(ESC)和OSKM重编程细胞中的表达。结果显示,这两种共抑制因子在三种细胞类型中都有表达。接下来,研究者敲除了用OSKM逆转录病毒转导的OG2 MEF中的NCOR1/2,结果显示敲除任何一个共抑制子都能显著增加Oct4绿色荧光蛋白阳性(...
BucherSWUVPZ-1NCO-T-ED-10 24V DC阀门 BuehlerNS 25/25-AM-K/ Schwimmer TypSK661 L1=1100mm流量计 BuehlerKontakt MKS 1/W-L 24V流量计附件 Buehler2889999 Kontakt MKS 1/W (Wechsler)液位计附件 Buehler2890999 Kontakt MKS 1/W-L 24V液位计附件 Buehler10937 NS 25/25 -AM /Schwimmer Typ SK661 ...
New developments in liquid scintillators, high-efficiency, fast photon detectors, and chromatic photon sorting have opened up the possibility for building a large-scale detector that can discriminate between Cherenkov and scintillation signals. Such a detector could reconstruct particle direction and specie...
V. et al. Recruitment of the NCoA/SRC-1/p160 family of transcriptional coactivators by the aryl hydrocarbon receptor/aryl hydrocarbon receptor nuclear translocator complex. Mol. Cell. Biol. 22, 4319–4333 (2002). CAS PubMed PubMed Central Google Scholar Wang, S. & Hankinson, O. ...
Furthermore, oral NMN administration (400 mg/kg/day) can improve the activity and stability of the ferroptosis core defence enzyme glutathione peroxidase 4 by promoting glutathione (GSH) recruitment (Feng et al., 2022), and NAD+-dependent SIRT6 can interfere with the interaction of NCOA4 ...
a Phase cycles used for data sets 1–4 are given in the caption to Fig. 9.13. 9.1.1 PROTEIN DEUTERATION Dramatically reducing the length of INEPT magnetization transfer periods, or other pulse sequence elements that rely on evolution under the scalar coupling Hamiltonian, in heteronuclear NMR exp...
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Closed-shell SCF MO calculations and geometry optimization were performed with the STO-3G, 3-21G and 6-31 G* basis sets for ten molecules containing the N Cl group: ClNC, ClNO, ClNO 2, ClNCO, ClNNN, Cl 3N, Cl 2NH, ClNH 2, ClNCH 2 and ClNCH(NH 2). The hydrogenation energies...
The turnover of ferritin, which is critical for iron mobilization and reutilization, involves the nuclear receptor coactivator 4 (NCOA4), a cargo receptor that binds to iron-loaded ferritin and mediates its autophagic degradation (ferritinophagy) in lysosomes [60]. 5. Crosstalk between iron and ...