Using the AM1153 strain, a derivative of AM1003, which contains theURA3gene inserted 3kbcentromereproximal toMATa, we collected DNA samples by the procedure described above and analyzed the kinetics of BIR repai
4a). In KEGG analysis, POLA1 was mainly associated with KEGG cytokine cytokine receptor interaction, KEGG gnrh signaling pathway, KEGG proximal tubule bicarbonate reclamation, while POLR3 C was involved in KEGG renin angiotensin system, KEGG base excision repair, KEGG glycosaminoglycan biosynthesis ...
Although merely a conceptual framework, the causal chain model of distal to proximate causes means that health researchers have a choice about where to focus their attention. One could (and should) investigate proximal causes of disease. But doing so to the exclusion of other factors will paint ...
Automation increasingly shapes modern society, requiring artificial intelligence (AI) systems to not only perform complex tasks but also provide clear, actionable explanations of their decisions, especially in high-stakes domains. However, most contemporary AI systems struggle to explain their runtime oper...
2 presents our proposed model that links facilitation to the proposed mediators (proximal outcomes) and targeted implementation outcomes (distal outcomes). Facilitation (e.g., dose, target) will be measured using the facilitation logs described in Aim 1; however, we will conceptualize facilitation ...
MR studies of SNPs proximal toHMGCR, the gene encoding the enzyme targeted by statins, suggest that increased risk of T2D noted with statins could at least partially be explained by HMGCR inhibition16. However, the multiple biochemical effects of statins have not been fully characterized at the ...
3c). To confirm that HNRNPC and PABPC4 act in concert to control the APA of HNRNPC targets, we performed 3′-end RNA-seq comparing HNRNPC/PABPC4 double KD cells with PABPC4 KD alone. Unlike Fig. 2e, in this comparison, we did not observe the significant proximal-to-distal switching ...
Generally, TE insertions are validated by PCR of the insertion allele using primers that amplify the entire TE with proximal flanking sequences, or 5′ and/or 3′ junctions of the insertion (Fig. 4A). Sanger sequencing of the PCR product allows further charac- terization of the insertion...
In the same year, the Proximal Policy Optimization (PPO) algorithm was also proposed (Schulman, Wolski, Dhariwal, Radford, & Klimov, 2017). The PPO algorithm is a new type of Policy Gradient algorithm. The Policy Gradient algorithm is very sensitive to the step size, but it is not easy ...
This model specifically considered the correlations at proximal positions of structural segments and dependencies to upstream and downstream residues. Besides, they implemented an iterative training method to refine estimates of HSMM parameters. On the basis of Ref. [87], Aydin et al. proposed ...