Bone tissue engineeringosteoinductiveosteoconductivebone remodellingmacrophagesBone tissue has the capability to regenerate itself; however, defects of a critical size prevent the bone from regenerating and req
Biodegradable polymer matrix nanocomposites for bone tissue engineering 1.2 Tissue engineering The term “tissue engineering” was officially defined in a National Science Foundation (NSF) workshop (United States) in 1988 as “the application of principles and methods of engineering and life sciences tow...
4). The prevascularized bone scaffolds will directly anastomose with host vessels, reducing the time for ECs to form vascular networks after implantation. Additive manufacturing (AM) techniques are great tools to advance prevascularized bone scaffolds. In bone tissue engineering, FDM is used to ...
Bone; Electrospinning; Biofibers; Nanostructure; Scaffold; Biological applications of polymers ABSTRACT The electrospinning method for scaffold production has emerged as a technique of great versatility within the field of tissue engineering. It is a relatively simple technique that enables scaffolds to be...
In bone tissue engineering research, bioreactors designed for replicating the main features of the complex native environment represent powerful investigation tools. Moreover, when equipped with automation, their use allows reducing user intervention and
Nature’s evolutionary mastery has perfected design over the years, yielding organisms superbly adapted to their surroundings. This research delves into the promising domain of bio-inspired designs, poised to revolutionize mechanical engineering. Leveraging insights drawn from prior conversations, we categor...
Introduction Hard tissue defects can arise following disease or trauma, including the excision of infected tissue and benign or cancerous growths. While bone exhibits a capacity to “self-heal” small defects, those larger than critical size require surgical intervention. In this case, bone graft ...
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1 Introduction Bone tissue is a composite material consisting primarily of cells, extracellular matrices, accessory proteins and the complex calcium phosphate salt hydroxyapatite (HAP) (Moreira, Dempster, & Baron, 2000; Sommerfeldt & Rubin, 2001; Zimmermann & Ritchie, 2015). HAP gives bone its str...
4.1 Introduction Bone tissue regeneration is one of the areas within tissue engineering that has gained considerable attention by the research community (Vacanti and Langer, 1999; Hench and Polak, 2002; Rose and Oreffo, 2002; Gomes and Reis, 2004). Critical size bone defects due to trauma or...