Intravenous immunoglobulin is approved for the following indications: primary immune deficiencies, immune-mediated thrombocytopenia, Kawasaki disease, bone marrow transplantation, chronic B cell lymphocytic leukemia, and pediatric HIV infection [217]. In addition, intravenous immunoglobulin is a promising immuno...
IMMUNOGLOBULIN ABIOMARKERSCYSTITISCOLOSTRUMUrinary tract infections (UTIs) are among the most common bacterial infections, affecting 150 million people worldwide each year. Although both men and women may become infected, UTIs are traditionally thought of as a disease of women...
Immunoglobulins are a group of closely related glycoproteins composed of 82 to 96% protein and 4 to 18% carbohydrate. In humans, there are five classes of immunoglobulins, which differ in heavy-chain structure. Immunoglobulin G (IgG) is the major class of immunoglobulins in blood and can be ...
Resistance represents a major challenge for antibody-based therapy for COVID-191,2,3,4. Here we engineered an immunoglobulin M (IgM) neutralizing antibody (IgM-14) to overcome the resistance encountered by immunoglobulin G (IgG)-based therapeutics. IgM-14 is over 230-fold more potent than its...
To fill this knowledge gap, we used a gain-of-function CRISPR activation (CRISPRa) screen. Paired immunoglobulin-like receptor B (PirB), which is a member of the leukocyte immunoglobulin-like receptor (LILR) family, was identified as a top candidate. PirB is expressed on immune cells35,36...
PROCEEDINGS: I IM MP PR RO OV VI IN NG G F FI IR RE EF FI IG GH HT TE ER R S SA AF FE ET TY Y: : H HU UM MA AN N B BE EH HA AV VI IO OR R A AN ND D O OR RG... RAK Ma,Mifiree 被引量: 0发表: 0年 I IM MP PR RO OV VI IN NG G F FI IR ...
(LDH)], cytomegalovirus immunoglobulin G (IgG) antibody (consistent with previous exposure), hepatitis A IgG antibody (consistent with previous infection), and Epstein-Barr virus capsid IgG antibody (consistent with recent or past infection). (From[1]Cohen PR, Kurzrock R: Sweet's syndrome ...
The domain is a folded β sheet structure formed by alternating antiparallel sequences connected by loop regions. This structure is called the “immunoglobulin fold” (15). The most important contribution to antibody flexibility is the hinge region between CH1 and CH2 domains. Movement of the “...
Each class of immunoglobulin can form a membrane-bound antigen receptor or a soluble secreted immunoglobulin (Fig. 6.1). Immunoglobulin G (IgG) consists of the basic unit but more complex molecules, such as IgM and IgA are made up from multiples of the unit, e.g. (H2L2)n. The H and ...
Here, we sequence the genomes of Aurelia aurita (a scyphozoan) and Morbakka virulenta (a cubozoan) to understand the molecular mechanisms responsible for the origin of the jellyfish body plan. We show that the magnitude of genetic differences between the two jellyfish types is equivalent, on ...