An FDA for Algorithmsdoi:10.2139/ssrn.2747994The rise of increasingly complex algorithms calls for critical thought about how best to prevent, deter, and compensate for the harms that they cause. This papSocial Science Electronic Publishing
Unlike other algorithms, the proposed algorithm creates time series for each drug and use it to identify start of a potential safety problem. A novel vectorized timeseries utilizing multiple attributes has been proposed here. First a time series with a small time period was created; then to ...
ALGORITHMSDATABASESDRUG side effectsIntroduction Although generic drugs constitute approximately 88% of drugs prescribed in the US, there are no reliable methods to identify generic drugs in the US FDA Adverse Event Reporting System (FAERS). Objective The aim of this study was to develop an ...
(1) the exclusion of a large number of phosphorylation sites from the human phosphoproteome, (2) high degrees of overlap between kinases, leading to a lack of discriminability for algorithms relying on these networks, and (3) high centrality of well-studied kinases and substrates (the more a ...
Kyoto Encyclopedia of Genes and Genomes (KEGG) is a database resource for understanding high-level functions in biological systems based on molecular datasets generated by genome sequencing and other high-throughput sequencing technologies (Kanehisa & Goto, 2000). From: Trends in Food Science & Techn...
Symmetric-key algorithms are generally much less computationally intensive which provides a smaller file size that allows for faster transmissions and less storage space. Cons: a. Key management: - One disadvantage of symmetric-key algorithms is the requirement of a shared secret key, with one copy...
Computational methods utilized for in silico aptamer identification include sequence-based, motif-searching-based, and multi-dimensional scoring-based algorithms, as well as supervised machine learning-based methods [30]. To understand the mechanisms of optimization aptamer-target interactions after obtaining...
(Fig.4a). Those observation indicate that AAVv128 capsid is at least as stable AAV8. The stability of a capsid variant is crucial for its commercial value and application prospects53. When moving into human use under the auspices of an FDA Investigational New Drug (IND) application, it is ...
Recently, similar algorithms for simultaneous sparse signal representation and discrimination have also been proposed in Feng et al. (2011), Rodriguez and Sapiro (2007), Kokiopoulou and Frossard (2008), Huang and Aviyente (2007), and Patel et al. (2010). The basic idea in learning a ...
including the FDA and CFDA, to provide a simple but dependable method for ADR signal detection and drug classification, as well as an auxiliary judgement basis for experts deciding on the status change of Rx drugs to OTC drugs. They propose that more ML or DL categorization algorithms be teste...