Hence, there is a need in the field of oncology to identify whether a patient might benefit from a kinase-inhibitor therapy and which kinase target(s) would be most beneficial. In recent years, due to advances in proteomics, large-scale monitoring of protein phosphorylation is closer to being...
What is an example of when a mutation could be beneficial? Give an example of a disorder that results from changes in the amino acid sequence. What is the effect of the mutations that cause Huntington's disease on the structure of the prot...
Gene mutations and their mechanism of action Mutation by definition refers to a permanent change in a coding region of the DNA sequence. Mutation can be beneficial or detrimental to the cell. Here mutation is being reviewed as detrimental to the cell. It is a well-known fact that mutations ...
Give an example of a disease-resistant variety of cultivated plant that has been produced by mutation. Mutation: When a DNA gene is destroyed or altered in such a way that the genetic message carried by that gene is altered, this is referred to as a mutat...
The development of disease is based upon one's genetic susceptibilities, complex interactions between initiating factors, and health status. In the aggregate, these can lead to disease progression, or not (Figure 17.1). For example, while the tubercle bacillus is the causative agent of tuberculosis...
In animals, maternal diet and environment can influence the health of offspring. Whether and how maternal dietary choice impacts the nervous system across multiple generations is not well understood. Here we show that feeding Caenorhabditis elegans with
The origin of sex is another shadowy avenue in eukaryote evolution. Many lines of evidence demonstrate that sex is beneficial for extant eukaryotes by creating genetic variability, masking or eliminating deleterious mutations, and assisting DNA repair processes [7–9]. Meiotic genes are however present...
A study on the mechanisms of Astragaloside IV (ASIV) in treating intracerebral hemorrhage (ICH) was selected as an example. Firstly, the absorbed ASIV metabolites were collected by a literature search. Next, the ADMET properties and the ICH-associated targets of ASIV and its metabolites were ...
Due to the redundancy of the code, mutations do not always result in alterations of the message. Frequently, the change of the third base of a codon does not modify its meaning; in this case the mutation is called “silent.” Moreover, even when a change in the codon determines the sub...
Point Mutation In subject area: Biochemistry, Genetics and Molecular Biology A point mutation is a substitution of a single nucleotide in the DNA sequence with another nucleotide which may or may not have a pathogenic effect. From: Differentiation, 2019 About this pageSet alert Also in subject ar...